KCNMB2

GENERAL INFORMATION

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Gene name

KCNMB2

Gene description

Potassium large conductance calcium-activated channel, subfamily M, beta member 2

Protein class

Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (fallopian tube, ovary)
GTEx:Tissue enhanced (ovary)

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues displayed weak to moderate cytoplasmic positivity. Renal glomeruli, spleen, ovarian and endometrial stroma cells were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB022649
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (fallopian tube, ovary)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (ovary)

Organ

Expression



GENE INFORMATION

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Gene name

KCNMB2

Synonyms

Description

Potassium large conductance calcium-activated channel, subfamily M, beta member 2 (HGNC Symbol)

Entrez gene summary

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]

Chromosome

3

Cytoband

q26.32

Chromosome location (bp)

178272932 - 178844429

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197584 (version 78.38)

Entrez gene

10242

UniProt

Q9Y691 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y691

Antibodypedia

KCNMB2 antibodies


PROTEIN BROWSER

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ENST00000358316
 
ENST00000420517
 
ENST00000432997
 
ENST00000437510
 
ENST00000452583
 
ENST00000455865
 
ENST00000617329
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNMB2-001 ENSP00000397483
ENST00000452583
Q9Y691
Show all »
Show » Show » 235 27.1 No 2
KCNMB2-002 ENSP00000395807
ENST00000437510
E7ETM2
Show all »
Show » Show » 137 15.8 No 1
KCNMB2-003 ENSP00000407592
ENST00000432997
Q9Y691
Show all »
Show » Show » 235 27.1 No 2
KCNMB2-004 ENSP00000408252
ENST00000420517
Q9Y691
Show all »
Show » Show » 235 27.1 No 2
KCNMB2-012 ENSP00000399100
ENST00000455865
E7EM81
Show all »
Show » Show » 100 11.6 No 1
KCNMB2-201 ENSP00000351068
ENST00000358316
Q9Y691
Show all »
Show » Show » 235 27.1 No 2
KCNMB2-202 ENSP00000484788
ENST00000617329
B5BNW5
Show all »
Show » Show » 216 25 No 2