DCAF12L2

GENERAL INFORMATION

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Gene name

DCAF12L2

Gene description

DDB1 and CUL4 associated factor 12-like 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (fallopian tube, testis)
GTEx:Tissue enhanced (testis)

Protein evidence

Evidence at transcript level

Protein localization

Cytoplasmic and membranous expression in e.g. ciliated cells of fallopian tube and glandular cells of the gastrointestinal tract.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation. Caution, targets protein from more than one gene.

Data reliability

Uncertain based on 3 antibodies.
HPA044737 , HPA048981 , HPA053138
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (fallopian tube, testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (testis)

Organ

Expression



GENE INFORMATION

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Gene name

DCAF12L2 (HGNC Symbol)

Synonyms

WDR40C

Description

DDB1 and CUL4 associated factor 12-like 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multi-protein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 9. However, the CDS of this intronless gene remains intact, it is conserved in other mammalian species, it is known to be transcribed, and it is therefore thought to encode a functional protein. [provided by RefSeq, May 2010]

Chromosome

X

Cytoband

q25

Chromosome location (bp)

126164531 - 126165951

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000198354 (version 78.38)

Entrez gene

340578

UniProt

Q5VW00 (UniProt - Evidence at transcript level)

neXtProt

NX_Q5VW00

Antibodypedia

DCAF12L2 antibodies


PROTEIN BROWSER

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ENST00000360028
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DCAF12L2-001 ENSP00000353128
ENST00000360028
Q5VW00
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