ITSN2

GENERAL INFORMATION

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Gene name

ITSN2

Gene description

Intersectin 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several tissues, highest in squamous epithelia and kidney.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA036475
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ITSN2 (HGNC Symbol)

Synonyms

KIAA1256, PRO2015, SH3D1B, SH3P18, SWA, SWAP

Description

Intersectin 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p23.3

Chromosome location (bp)

24202864 - 24360714

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198399 (version 78.38)

Entrez gene

50618

UniProt

Q9NZM3 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NZM3

Antibodypedia

ITSN2 antibodies


PROTEIN BROWSER

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ENST00000355123
 
ENST00000361999
 
ENST00000406921
 
ENST00000412011
 
ENST00000416160
 
ENST00000443927
 
ENST00000622089
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ITSN2-001 ENSP00000347244
ENST00000355123
Q9NZM3
Show all »
Show » Show » 1697 193.5 No 0
ITSN2-002 ENSP00000354561
ENST00000361999
Q9NZM3
Show all »
Show » Show » 1670 190.5 No 0
ITSN2-003 ENSP00000391224
ENST00000412011
E7EPJ2
Show all »
Show » Show » 609 69 No 0
ITSN2-004 ENSP00000384499
ENST00000406921
Q9NZM3
Show all »
Show » Show » 1249 141.8 No 0
ITSN2-008 ENSP00000389013
ENST00000416160
Show » Show » 120 13.3 No 0
ITSN2-012 ENSP00000391715
ENST00000443927
F8W719
Show all »
Show » Show » 184 19.8 No 0
ITSN2-201 ENSP00000479408
ENST00000622089
Q53TM3
Show all »
Show » Show » 1680 191.6 No 0