CHUK

GENERAL INFORMATION

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Gene name

CHUK

Gene description

Conserved helix-loop-helix ubiquitous kinase

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA001402 , CAB004240 , CAB018564
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CHUK (HGNC Symbol)

Synonyms

IkBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16

Description

Conserved helix-loop-helix ubiquitous kinase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q24.31

Chromosome location (bp)

100188298 - 100229619

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000213341 (version 78.38)

Entrez gene

1147

UniProt

O15111 (UniProt - Evidence at protein level)

neXtProt

NX_O15111

Antibodypedia

CHUK antibodies


PROTEIN BROWSER

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ENST00000370397
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHUK-001 ENSP00000359424
ENST00000370397
O15111
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