MPP1

GENERAL INFORMATION

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Gene name

MPP1

Gene description

Membrane protein, palmitoylated 1, 55kDa

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Placenta, seminal vesicle, pancreas, adrenal gland, lung and some glandular cells in gastrointestinal tract showed moderate cytoplasmic positivity. Remaining normal cells were generally negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA000884
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MPP1 (HGNC Symbol)

Synonyms

DXS552E, PEMP

Description

Membrane protein, palmitoylated 1, 55kDa (HGNC Symbol)

Entrez gene summary

This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Chromosome

X

Cytoband

q28

Chromosome location (bp)

154778684 - 154821007

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000130830 (version 78.38)

Entrez gene

4354

UniProt

Q00013 (UniProt - Evidence at protein level)

neXtProt

NX_Q00013

Antibodypedia

MPP1 antibodies


PROTEIN BROWSER

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ENST00000369531
 
ENST00000369534
 
ENST00000393529
 
ENST00000393531
 
ENST00000413259
 
ENST00000428488
 
ENST00000453245
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MPP1-005 ENSP00000358544
ENST00000369531
A6NFY0
Show all »
Show » Show » 131 14.1 No 0
MPP1-006 ENSP00000358547
ENST00000369534
Q00013
Show all »
Show » Show » 466 52.3 No 0
MPP1-009 ENSP00000377165
ENST00000393531
Q00013
Show all »
Show » Show » 446 49.9 No 0
MPP1-010 ENSP00000391701
ENST00000428488
C9JB34
Show all »
Show » Show » 156 17.5 No 0
MPP1-011 ENSP00000410888
ENST00000453245
C9J9J4
Show all »
Show » Show » 205 23.1 No 0
MPP1-016 ENSP00000377163
ENST00000393529
A8MTH1
Show all »
Show » Show » 241 26.9 No 0
MPP1-201 ENSP00000400155
ENST00000413259
Q00013
Show all »
Show » Show » 436 49.1 No 0