CAPN14

GENERAL INFORMATION

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Gene name

CAPN14

Gene description

Calpain 14

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (esophagus)
GTEx:Tissue enriched (esophagus)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression in esophagus. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 2 antibodies.
HPA035720 , HPA035721
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (esophagus)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (esophagus)

Organ

Expression



GENE INFORMATION

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Gene name

CAPN14

Synonyms

Description

Calpain 14 (HGNC Symbol)

Entrez gene summary

Calpains are a family of cytosolic calcium-activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin-cytoskeletal interactions, and synaptic plasticity (Dear et al., 2000 [PubMed 10964513]). CAPN14 belongs to the calpain large subunit family.[supplied by OMIM, Mar 2008]

Chromosome

2

Cytoband

p23.1

Chromosome location (bp)

31173056 - 31233858

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000214711 (version 78.38)

Entrez gene

440854

UniProt

A8MX76 (UniProt - Evidence at transcript level)

neXtProt

NX_A8MX76

Antibodypedia

CAPN14 antibodies


PROTEIN BROWSER

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ENST00000403897
 
ENST00000444918
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CAPN14-002 ENSP00000385247
ENST00000403897
A8MX76
Show all »
Show » Show » 684 79.6 No 0
CAPN14-201 ENSP00000398670
ENST00000444918
D6W573
Show all »
Show » Show » 681 79.2 No 0