The human protein atlas blog

Image of the week - Long live the long-living lens proteins

Eye Image of the week Immunohistochemistry Lens proteins

The beta-crystallin B2 protein, encoded by the CRYBB2 gene, is a very important structural component of the human eye lens. Immunohistochemical staining of CRYBB2 protein shows specific expression in the lens.

Previously we have highlighted proteins expressed in the human neural retina. Today, we will focus on the lens and shed light on its structure and function, and hopefully spark an interest in you for the proteins of the lens.

The main function of the lens is to focus light on the retina. The passage of light through the cornea, lens and vitreous all the way to the retinal layer of the eye is only possible due to transparency of the tissue. Although the lens is very protein-rich, light absorption and light scattering in the lens is minimal.

The lens comprise of non-diving lens cells which are mainly composed of ordered proteins called crystallins...Read more

Image of the week - TPX2

Cell Atlas Cell cycle Image of the week Kinetochore

Mitotic spindle with TPX2 expression (green)

Let‘s have a look at the protein TPX2, a microtubule nucleation factor that translocates from the nucleus - where it resides during interphase - to the mitotic spindle during mitosis.

The mitotic spindle forms when chromosomes are ready to segregate during cell division and not surprisingly this protein is also found in this specific compartment of the cell! TPX2 is required for the correct formation of the kinetochores that is crucial for the attachment of microtubules, enabling the sister chromatids to be pulled apart...Read more

Welcome to Tissue Atlas Image of the month!

Brain Image of the week Immunohistochemistry Pituitary gland Tissue Atlas

Today, you will be introduced to the master gland in the body - the pituitary gland.

The pituitary gland plays a crucial role in human physiology, and together with the hypothalamus this highly conserved and elegant system form a link between the nervous and endocrine system, by controlling the functions of the thyroid, adrenal glands, and the gonads, and also regulating growth, lactation, and water preservation.

The pituitary gland, also called hypophysis, consists of two separate lobes with dual embryonic origin; the anterior (adeno) pituitary gland originates from the oral cavity, and the posterior (neural) pituitary gland develops from the neural plate...Read more

Cell Image of the Month - It is Taco Friday!

Cell Atlas Image of the week Mitochondria

Antibody HPA021643 in U-2 OS recognizing TACO1 in mitochondria.

Today we highlight another part of Swedish or Scandinavian (food) culture - "Taco Fredag" or "Taco Friday". Doesn't sound Swedish to you? But staying in on a Friday night and having tacos with your family and/or friends is a thing here, and a big thing as it happens, with supermarkets having entire sections dedicated to this tradition.

So what other image to look at in this week's edition of the Human Protein Atlas blog than the one representing TACO1. TACO1 acts as a translational activator for the mitochondrial encoded cytochrome c oxidase 1, which is a component of complex IV of the mitochondrial respiratory complex...Read more

Image of the week - renal cell cancer

Image of the week Renal Cell Carcinoma

It is Friday, and time for another image of the week, today from our Cancer Atlas group!

Renal cell cancer is a relatively common form of human cancer. Tumors develop in the kidney and have a tendency to grow into renal veins and metastasize to distant organs without the spread to regional lymph nodes as is common for many other tumor types. This particular case shows a papillary form of renal cell cancer that grows with papillary excrescences into cyst formations and with areas of necrosis.

This tumor has been stained with an antibody (HPA005785) that recognizes the CD44 protein...Read more