Brain tissue expression of MAP2 in pons

PONS - Expression summary

Mouse brain, Intensity
Ponsⁱ

43.286

RNA expressionⁱ

HPA Brain:	460.1	nTPM
FANTOM5:	795.0	Scaled Tags Per Million

Macaque:	324.9	nTPM
Mouse:	311.3	nTPM
Rat:	389.2	nTPM
Pig:	443.3	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - Mouse brain profileⁱ Protein expression in mouse brain using immunofluorescence is reported as fluorescence intensity. , antibody HPA012828
Pons mean intensity	43.286
	intensityⁱ Protein expression in mouse brain using immunofluorescence is reported as mean fluorescence intensity.	FRONT BACK
Barrington's nucleus	-
Koelliker-fuse nucleus	-
Motor tregiminal nucleus	31.401
Parabrachial nucleus	18.626
Principle sensory trigeminal nucleus	20.059
Locus coeruleus	-
Pontine nucleus	33.475
Vestibular nucleus	43.286
Pontine reticular nucleus, oral	21.661
Lateral lemniscus	24.634
Superior paraolivary nucleus	18.007

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	460.1

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 154.8

2301	Female, age 85, both hemispheres	173.9
1984	Male, age 76, both hemispheres	169.8
2090	Male, age 80, both hemispheres	144.7
2188	Female, age 91, both hemispheres	130.9

Dorsal cochlear nucleus
nTPM: 191.2

2058	Male, age 76, both hemispheres	250.7
2187	Female, age 91, both hemispheres	241.4
2370	Male, age 61, both hemispheres	197.8
2802	Male, age 74, right hemisphere	140.7
2378	Male, age 80, both hemispheres	125.6

Dorsal tegmental nucleus
nTPM: 234.8

2083	Male, age 80, both hemispheres	279.0
1936	Male, age 76, left hemisphere	239.0
2358	Male, age 61, both hemispheres	230.6
2326	Male, age 74, both hemispheres	190.8

Dorsolateral tegmental area
nTPM: 226.9

2141	Male, age 76, both hemispheres	306.6
2654	Male, age 80, both hemispheres	285.2
2360	Male, age 74, both hemispheres	216.7
2751	Female, age 85, both hemispheres	212.2
2337	Male, age 61, both hemispheres	114.1

Kolliker-Fuse nucleus
nTPM: 227.9

2163	Male, age 80, both hemispheres	388.0
2793	Female, age 91, left hemisphere	151.6
2315	Male, age 76, right hemisphere	144.1

Lateral lemniscal nuclei
nTPM: 255.0

2169	Male, age 76, both hemispheres	366.6
2453	Male, age 74, right hemisphere	275.9
2036	Male, age 80, both hemispheres	260.0
2746	Female, age 85, left hemisphere	213.5
2320	Female, age 91, left hemisphere	159.0

Lateral parabrachial nucleus
nTPM: 203.2

2139	Female, age 85, right hemisphere	283.7
2790	Male, age 61, both hemispheres	245.1
2013	Male, age 80, both hemispheres	191.5
2792	Male, age 76, both hemispheres	92.5

Lateral vestibular nucleus
nTPM: 286.5

2184	Male, age 76, both hemispheres	350.8
2311	Male, age 80, both hemispheres	222.2

Locus coeruleus
nTPM: 460.1

2720	Male, age 74, both hemispheres	584.2
2123	Female, age 91, both hemispheres	572.9
2788	Male, age 74, unknown	455.8
2014	Male, age 55, unknown	439.9
2317	Female, age 72, unknown	395.2
2162	Male, age 80, both hemispheres	392.3
1980	Male, age 76, both hemispheres	380.8

Medial parabrachial nucleus
nTPM: 256.0

2786	Male, age 76, both hemispheres	295.5
2854	Male, age 80, both hemispheres	278.5
2156	Male, age 61, both hemispheres	271.2
2170	Female, age 91, both hemispheres	260.2
2463	Female, age 85, right hemisphere	174.7

Medial periolivary nuclei
nTPM: 236.9

2063	Male, age 76, both hemispheres	349.0
2171	Female, age 85, both hemispheres	342.0
2791	Male, age 74, right hemisphere	214.5
2458	Female, age 91, both hemispheres	147.0
2081	Male, age 80, both hemispheres	131.8

Motor facial nucleus
nTPM: 253.3

2062	Male, age 76, both hemispheres	363.1
2365	Male, age 74, right hemisphere	265.2
2327	Male, age 80, both hemispheres	252.0
2697	Female, age 85, both hemispheres	238.7
2126	Male, age 61, both hemispheres	219.9
2795	Female, age 91, both hemispheres	181.0

Motor trigeminal nucleus
nTPM: 229.1

2309	Male, age 76, both hemispheres	277.5
2335	Male, age 61, both hemispheres	269.5
2079	Male, age 80, both hemispheres	235.5
2560	Male, age 74, both hemispheres	200.6
2321	Female, age 91, both hemispheres	162.3

Nuclei of the trapezoid body
nTPM: 276.3

2159	Male, age 61, both hemispheres	357.5
2735	Female, age 85, both hemispheres	331.4
1983	Male, age 76, both hemispheres	318.8
2166	Male, age 80, both hemispheres	207.4
2368	Female, age 91, both hemispheres	166.6

Nucleus raphe magnus
nTPM: 311.5

2160	Male, age 61, both hemispheres	477.1
2172	Female, age 85, both hemispheres	386.5
2455	Male, age 74, both hemispheres	364.9
2328	Male, age 80, both hemispheres	235.3
2051	Male, age 76, both hemispheres	233.4
2459	Female, age 91, both hemispheres	171.6

Paramedian reticular nucleus
nTPM: 307.3

2050	Female, age 85, both hemispheres	356.5
2313	Male, age 61, both hemispheres	351.3
2057	Male, age 80, both hemispheres	290.8
2052	Male, age 76, both hemispheres	230.5

Pedunculopontine tegmental nucleus
nTPM: 285.0

2334	Male, age 80, both hemispheres	323.7
1921	Female, age 85, both hemispheres	298.2
2338	Male, age 61, both hemispheres	233.2

Pontine nuclei
nTPM: 265.7

2727	Male, age 61, right hemisphere	415.1
2787	Female, age 85, both hemispheres	355.8
1863	Male, age 55, unknown	307.2
1968	Male, age 76, left hemisphere	286.1
2109	Female, age 72, unknown	279.4
2454	Male, age 74, left hemisphere	196.7
2115	Male, age 80, left hemisphere	150.2
2319	Female, age 91, both hemispheres	135.0

Pontine raphe nucleus
nTPM: 350.1

2853	Male, age 76, midline	356.4
2122	Female, age 85, midline	343.8

Posteroventral cochlear nucleus
nTPM: 191.2

2752	Female, age 85, both hemispheres	419.7
2070	Male, age 76, both hemispheres	253.0
2371	Male, age 61, both hemispheres	160.9
2341	Male, age 80, both hemispheres	85.0
2135	Female, age 91, both hemispheres	37.1

Principal sensory trigeminal nucleus
nTPM: 287.7

2158	Male, age 61, both hemispheres	408.2
2324	Male, age 76, both hemispheres	321.7
2008	Male, age 80, left hemisphere	278.1
2367	Female, age 91, left hemisphere	142.6

Reticular pontine nucleus, caudal
nTPM: 216.6

2092	Male, age 76, both hemispheres	265.3
2332	Male, age 80, right hemisphere	258.1
2559	Male, age 74, both hemispheres	202.4
2457	Female, age 91, both hemispheres	140.5

Reticular pontine nucleus, oral
nTPM: 241.7

2361	Male, age 74, both hemispheres	300.3
2012	Female, age 85, both hemispheres	270.7
2167	Male, age 76, both hemispheres	267.6
1939	Male, age 80, both hemispheres	233.9
2366	Female, age 91, both hemispheres	136.1

Reticulotegmental nucleus
nTPM: 255.9

2325	Male, age 76, both hemispheres	351.2
2322	Female, age 91, both hemispheres	239.6
2452	Male, age 74, both hemispheres	219.9
2333	Male, age 80, both hemispheres	213.1

Spinal trigeminal nucleus, oral
nTPM: 298.7

2737	Female, age 85, both hemispheres	313.3
2164	Male, age 80, both hemispheres	304.5
1978	Male, age 76, both hemispheres	278.4

Subcoeruleus area
nTPM: 313.3

2323	Female, age 91, left hemisphere	499.8
1958	Male, age 80, both hemispheres	335.6
2451	Male, age 74, both hemispheres	283.8
2089	Male, age 76, left hemisphere	274.2
2369	Female, age 85, left hemisphere	173.3

Superior olive
nTPM: 232.1

1875	Female, age 85, both hemispheres	324.6
2020	Male, age 76, both hemispheres	236.7
2364	Male, age 74, right hemisphere	220.3
2329	Male, age 80, right hemisphere	201.6
2561	Female, age 91, both hemispheres	177.4

Ventral periolivary nuclei
nTPM: 270.5

2130	Female, age 85, both hemispheres	345.8
2165	Male, age 80, both hemispheres	284.9
2794	Female, age 91, left hemisphere	232.3
2023	Male, age 76, both hemispheres	218.9

Ventrolateral tegmental area, A5 NE cell group
nTPM: 233.1

2449	Male, age 74, both hemispheres	316.6
2840	Female, age 85, both hemispheres	296.6
1959	Male, age 76, both hemispheres	251.9
2359	Male, age 61, both hemispheres	223.3
2161	Male, age 80, both hemispheres	194.6
2456	Female, age 91, both hemispheres	115.4

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	795.0

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 795.0

FF:10182-103D2	60 years, female	1024.1
FF:10165-103B3	76 years, female	565.8

Pons
Scaled Tags Per Million: 791.0

FF:10033-101E6

18-54 years, mixed

791.0

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	324.9

Macaque sample

Sample description

nTPM

Pons
nTPM: 324.9

Samples: 2

Max nTPM: 386.4
Min nTPM: 263.3

Sample A		386.4
Sample B		263.3

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	443.3

Pig sample

Sample description

nTPM

Pons
nTPM: 443.3

Samples: 3

Max nTPM: 500.3
Min nTPM: 407.9

Sample A	Female	500.3
Sample B	Female	407.9
Sample C	Male	421.8

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	311.3

Mouse sample

Sample description

nTPM

Pons
nTPM: 311.3

Samples: 4

Max nTPM: 328.2
Min nTPM: 297.3

Sample A		328.2
Sample B		297.9
Sample C		322.0
Sample D		297.3

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	389.2

Rat sample

Sample description

nTPM

Pons
nTPM: 389.2

Samples: 4

Max nTPM: 399.0
Min nTPM: 372.3

Sample A		393.3
Sample A		392.2
Sample A		372.3
Sample A		399.0