Brain tissue expression of CALM2 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	812.0	nTPM
FANTOM5:	1290.6	Scaled Tags Per Million

Macaque:	1.9	nTPM
Mouse:	444.0	nTPM
Rat:	512.4	nTPM
Pig:	1290.5	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	812.0

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 634.2

2188	Female, age 91, both hemispheres	758.3
2301	Female, age 85, both hemispheres	652.3
2090	Male, age 80, both hemispheres	591.8
1984	Male, age 76, both hemispheres	534.3

Dorsal cochlear nucleus
nTPM: 610.7

2802	Male, age 74, right hemisphere	750.9
2187	Female, age 91, both hemispheres	724.0
2378	Male, age 80, both hemispheres	558.3
2058	Male, age 76, both hemispheres	529.5
2370	Male, age 61, both hemispheres	490.9

Dorsal tegmental nucleus
nTPM: 615.1

2326	Male, age 74, both hemispheres	770.9
2083	Male, age 80, both hemispheres	663.4
1936	Male, age 76, left hemisphere	618.4
2358	Male, age 61, both hemispheres	407.8

Dorsolateral tegmental area
nTPM: 592.4

2751	Female, age 85, both hemispheres	765.5
2654	Male, age 80, both hemispheres	624.7
2360	Male, age 74, both hemispheres	623.2
2141	Male, age 76, both hemispheres	478.8
2337	Male, age 61, both hemispheres	469.6

Kolliker-Fuse nucleus
nTPM: 665.8

2163	Male, age 80, both hemispheres	718.0
2793	Female, age 91, left hemisphere	695.9
2315	Male, age 76, right hemisphere	583.5

Lateral lemniscal nuclei
nTPM: 674.6

2169	Male, age 76, both hemispheres	747.9
2453	Male, age 74, right hemisphere	698.5
2746	Female, age 85, left hemisphere	673.0
2036	Male, age 80, both hemispheres	638.1
2320	Female, age 91, left hemisphere	615.5

Lateral parabrachial nucleus
nTPM: 644.9

2139	Female, age 85, right hemisphere	720.8
2792	Male, age 76, both hemispheres	695.1
2013	Male, age 80, both hemispheres	680.4
2790	Male, age 61, both hemispheres	483.3

Lateral vestibular nucleus
nTPM: 626.6

2184	Male, age 76, both hemispheres	667.2
2311	Male, age 80, both hemispheres	585.9

Locus coeruleus
nTPM: 677.7

2014	Male, age 55, unknown	776.2
2788	Male, age 74, unknown	756.6
2123	Female, age 91, both hemispheres	741.6
2720	Male, age 74, both hemispheres	677.3
2317	Female, age 72, unknown	642.6
2162	Male, age 80, both hemispheres	591.5
1980	Male, age 76, both hemispheres	558.1

Medial parabrachial nucleus
nTPM: 637.6

2170	Female, age 91, both hemispheres	800.4
2854	Male, age 80, both hemispheres	692.8
2463	Female, age 85, right hemisphere	612.9
2786	Male, age 76, both hemispheres	562.3
2156	Male, age 61, both hemispheres	519.4

Medial periolivary nuclei
nTPM: 740.1

2791	Male, age 74, right hemisphere	986.6
2171	Female, age 85, both hemispheres	798.6
2063	Male, age 76, both hemispheres	779.7
2081	Male, age 80, both hemispheres	588.9
2458	Female, age 91, both hemispheres	546.8

Motor facial nucleus
nTPM: 703.6

2365	Male, age 74, right hemisphere	863.1
2062	Male, age 76, both hemispheres	823.6
2697	Female, age 85, both hemispheres	693.1
2126	Male, age 61, both hemispheres	640.6
2795	Female, age 91, both hemispheres	635.5
2327	Male, age 80, both hemispheres	565.7

Motor trigeminal nucleus
nTPM: 584.3

2560	Male, age 74, both hemispheres	700.3
2079	Male, age 80, both hemispheres	623.3
2321	Female, age 91, both hemispheres	575.8
2309	Male, age 76, both hemispheres	566.6
2335	Male, age 61, both hemispheres	455.6

Nuclei of the trapezoid body
nTPM: 762.2

2159	Male, age 61, both hemispheres	1022.8
1983	Male, age 76, both hemispheres	832.3
2735	Female, age 85, both hemispheres	762.6
2166	Male, age 80, both hemispheres	600.8
2368	Female, age 91, both hemispheres	592.6

Nucleus raphe magnus
nTPM: 732.0

2160	Male, age 61, both hemispheres	980.1
2455	Male, age 74, both hemispheres	801.7
2051	Male, age 76, both hemispheres	711.9
2172	Female, age 85, both hemispheres	703.5
2328	Male, age 80, both hemispheres	601.5
2459	Female, age 91, both hemispheres	593.2

Paramedian reticular nucleus
nTPM: 742.5

2050	Female, age 85, both hemispheres	837.5
2313	Male, age 61, both hemispheres	770.1
2052	Male, age 76, both hemispheres	712.5
2057	Male, age 80, both hemispheres	649.9

Pedunculopontine tegmental nucleus
nTPM: 649.2

2334	Male, age 80, both hemispheres	671.3
1921	Female, age 85, both hemispheres	654.0
2338	Male, age 61, both hemispheres	622.4

Pontine nuclei
nTPM: 812.0

2454	Male, age 74, left hemisphere	1028.3
2727	Male, age 61, right hemisphere	985.5
1863	Male, age 55, unknown	945.2
2109	Female, age 72, unknown	865.9
2787	Female, age 85, both hemispheres	740.2
2319	Female, age 91, both hemispheres	722.0
1968	Male, age 76, left hemisphere	699.5
2115	Male, age 80, left hemisphere	509.4

Pontine raphe nucleus
nTPM: 693.1

2122	Female, age 85, midline	764.5
2853	Male, age 76, midline	621.7

Posteroventral cochlear nucleus
nTPM: 653.0

2135	Female, age 91, both hemispheres	735.0
2341	Male, age 80, both hemispheres	729.9
2752	Female, age 85, both hemispheres	707.7
2070	Male, age 76, both hemispheres	591.6
2371	Male, age 61, both hemispheres	500.5

Principal sensory trigeminal nucleus
nTPM: 697.5

2158	Male, age 61, both hemispheres	747.1
2008	Male, age 80, left hemisphere	710.1
2367	Female, age 91, left hemisphere	693.3
2324	Male, age 76, both hemispheres	639.3

Reticular pontine nucleus, caudal
nTPM: 700.8

2559	Male, age 74, both hemispheres	854.2
2092	Male, age 76, both hemispheres	717.5
2457	Female, age 91, both hemispheres	704.7
2332	Male, age 80, right hemisphere	526.8

Reticular pontine nucleus, oral
nTPM: 745.8

2361	Male, age 74, both hemispheres	850.6
1939	Male, age 80, both hemispheres	777.6
2366	Female, age 91, both hemispheres	742.6
2012	Female, age 85, both hemispheres	725.0
2167	Male, age 76, both hemispheres	633.1

Reticulotegmental nucleus
nTPM: 636.7

2322	Female, age 91, both hemispheres	699.6
2325	Male, age 76, both hemispheres	639.2
2452	Male, age 74, both hemispheres	637.3
2333	Male, age 80, both hemispheres	570.5

Spinal trigeminal nucleus, oral
nTPM: 628.6

2737	Female, age 85, both hemispheres	662.4
2164	Male, age 80, both hemispheres	651.4
1978	Male, age 76, both hemispheres	572.1

Subcoeruleus area
nTPM: 673.9

1958	Male, age 80, both hemispheres	773.8
2369	Female, age 85, left hemisphere	751.2
2323	Female, age 91, left hemisphere	640.7
2451	Male, age 74, both hemispheres	606.9
2089	Male, age 76, left hemisphere	596.8

Superior olive
nTPM: 737.4

2364	Male, age 74, right hemisphere	916.2
1875	Female, age 85, both hemispheres	866.8
2020	Male, age 76, both hemispheres	756.8
2329	Male, age 80, right hemisphere	584.2
2561	Female, age 91, both hemispheres	563.2

Ventral periolivary nuclei
nTPM: 686.5

2023	Male, age 76, both hemispheres	814.8
2165	Male, age 80, both hemispheres	693.4
2130	Female, age 85, both hemispheres	671.3
2794	Female, age 91, left hemisphere	566.7

Ventrolateral tegmental area, A5 NE cell group
nTPM: 664.8

2449	Male, age 74, both hemispheres	761.5
1959	Male, age 76, both hemispheres	751.7
2840	Female, age 85, both hemispheres	720.5
2161	Male, age 80, both hemispheres	607.0
2359	Male, age 61, both hemispheres	591.1
2456	Female, age 91, both hemispheres	556.8

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	1290.6

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 1290.6

FF:10182-103D2	60 years, female	1431.9
FF:10165-103B3	76 years, female	1149.3

Pons
Scaled Tags Per Million: 1183.3

FF:10033-101E6

18-54 years, mixed

1183.3

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	1.9

Macaque sample

Sample description

nTPM

Pons
nTPM: 1.9

Samples: 2

Max nTPM: 2.0
Min nTPM: 1.8

Sample A		2.0
Sample B		1.8

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	1290.5

Pig sample

Sample description

nTPM

Pons
nTPM: 1290.5

Samples: 3

Max nTPM: 1551.1
Min nTPM: 882.8

Sample A	Female	1551.1
Sample B	Female	882.8
Sample C	Male	1437.6

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	444.0

Mouse sample

Sample description

nTPM

Pons
nTPM: 444.1

Samples: 4

Max nTPM: 541.1
Min nTPM: 384.1

Sample A		541.1
Sample B		384.1
Sample C		437.1
Sample D		413.9

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	512.4

Rat sample

Sample description

nTPM

Pons
nTPM: 512.4

Samples: 4

Max nTPM: 533.9
Min nTPM: 492.1

Sample A		503.0
Sample A		533.9
Sample A		492.1
Sample A		520.7