Brain tissue expression of RPL7A in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	241.5	nTPM
FANTOM5:	42.8	Scaled Tags Per Million

Macaque:	3.8	nTPM
Mouse:	257.7	nTPM
Pig:	4.9	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
Show allShow less

This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
Show allShow less

This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - Annotated protein expression
Pending normal tissue analysis

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	241.5

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 222.1

2090	Male, age 80, both hemispheres	251.8
2188	Female, age 91, both hemispheres	225.9
2301	Female, age 85, both hemispheres	211.6
1984	Male, age 76, both hemispheres	199.0

Dorsal cochlear nucleus
nTPM: 235.5

2802	Male, age 74, right hemisphere	283.4
2378	Male, age 80, both hemispheres	237.0
2187	Female, age 91, both hemispheres	234.2
2058	Male, age 76, both hemispheres	211.6
2370	Male, age 61, both hemispheres	211.1

Dorsal tegmental nucleus
nTPM: 232.3

2358	Male, age 61, both hemispheres	259.0
2326	Male, age 74, both hemispheres	241.7
2083	Male, age 80, both hemispheres	236.4
1936	Male, age 76, left hemisphere	192.2

Dorsolateral tegmental area
nTPM: 230.3

2337	Male, age 61, both hemispheres	316.6
2654	Male, age 80, both hemispheres	237.9
2751	Female, age 85, both hemispheres	210.4
2360	Male, age 74, both hemispheres	203.7
2141	Male, age 76, both hemispheres	183.1

Kolliker-Fuse nucleus
nTPM: 225.4

2315	Male, age 76, right hemisphere	241.1
2793	Female, age 91, left hemisphere	218.2
2163	Male, age 80, both hemispheres	217.0

Lateral lemniscal nuclei
nTPM: 206.5

2169	Male, age 76, both hemispheres	244.7
2746	Female, age 85, left hemisphere	230.5
2320	Female, age 91, left hemisphere	201.6
2453	Male, age 74, right hemisphere	201.4
2036	Male, age 80, both hemispheres	154.5

Lateral parabrachial nucleus
nTPM: 235.7

2139	Female, age 85, right hemisphere	240.2
2792	Male, age 76, both hemispheres	238.2
2013	Male, age 80, both hemispheres	235.0
2790	Male, age 61, both hemispheres	229.4

Lateral vestibular nucleus
nTPM: 221.6

2311	Male, age 80, both hemispheres	255.2
2184	Male, age 76, both hemispheres	188.0

Locus coeruleus
nTPM: 195.0

2720	Male, age 74, both hemispheres	217.2
2123	Female, age 91, both hemispheres	204.6
2162	Male, age 80, both hemispheres	203.6
2014	Male, age 55, unknown	195.0
2317	Female, age 72, unknown	192.4
2788	Male, age 74, unknown	181.5
1980	Male, age 76, both hemispheres	170.5

Medial parabrachial nucleus
nTPM: 211.7

2170	Female, age 91, both hemispheres	253.4
2854	Male, age 80, both hemispheres	215.9
2463	Female, age 85, right hemisphere	207.9
2156	Male, age 61, both hemispheres	198.0
2786	Male, age 76, both hemispheres	183.4

Medial periolivary nuclei
nTPM: 234.3

2063	Male, age 76, both hemispheres	299.0
2171	Female, age 85, both hemispheres	238.0
2081	Male, age 80, both hemispheres	234.3
2458	Female, age 91, both hemispheres	203.1
2791	Male, age 74, right hemisphere	197.4

Motor facial nucleus
nTPM: 226.5

2062	Male, age 76, both hemispheres	302.1
2795	Female, age 91, both hemispheres	236.5
2126	Male, age 61, both hemispheres	229.2
2365	Male, age 74, right hemisphere	217.4
2697	Female, age 85, both hemispheres	200.5
2327	Male, age 80, both hemispheres	173.3

Motor trigeminal nucleus
nTPM: 209.5

2560	Male, age 74, both hemispheres	219.3
2335	Male, age 61, both hemispheres	214.6
2321	Female, age 91, both hemispheres	205.7
2079	Male, age 80, both hemispheres	204.2
2309	Male, age 76, both hemispheres	203.5

Nuclei of the trapezoid body
nTPM: 241.5

1983	Male, age 76, both hemispheres	352.6
2735	Female, age 85, both hemispheres	237.4
2159	Male, age 61, both hemispheres	211.8
2166	Male, age 80, both hemispheres	205.6
2368	Female, age 91, both hemispheres	200.1

Nucleus raphe magnus
nTPM: 215.6

2051	Male, age 76, both hemispheres	247.4
2172	Female, age 85, both hemispheres	235.4
2160	Male, age 61, both hemispheres	214.3
2459	Female, age 91, both hemispheres	206.0
2455	Male, age 74, both hemispheres	204.4
2328	Male, age 80, both hemispheres	186.5

Paramedian reticular nucleus
nTPM: 205.9

2057	Male, age 80, both hemispheres	216.3
2050	Female, age 85, both hemispheres	215.4
2052	Male, age 76, both hemispheres	204.4
2313	Male, age 61, both hemispheres	187.7

Pedunculopontine tegmental nucleus
nTPM: 217.9

2338	Male, age 61, both hemispheres	278.8
2334	Male, age 80, both hemispheres	212.1
1921	Female, age 85, both hemispheres	162.9

Pontine nuclei
nTPM: 239.6

1968	Male, age 76, left hemisphere	294.6
1863	Male, age 55, unknown	272.6
2787	Female, age 85, both hemispheres	267.5
2115	Male, age 80, left hemisphere	226.3
2109	Female, age 72, unknown	223.7
2319	Female, age 91, both hemispheres	222.4
2727	Male, age 61, right hemisphere	217.4
2454	Male, age 74, left hemisphere	191.9

Pontine raphe nucleus
nTPM: 201.4

2122	Female, age 85, midline	217.0
2853	Male, age 76, midline	185.8

Posteroventral cochlear nucleus
nTPM: 231.1

2341	Male, age 80, both hemispheres	260.5
2371	Male, age 61, both hemispheres	244.0
2135	Female, age 91, both hemispheres	229.1
2752	Female, age 85, both hemispheres	211.6
2070	Male, age 76, both hemispheres	210.5

Principal sensory trigeminal nucleus
nTPM: 204.4

2158	Male, age 61, both hemispheres	225.3
2008	Male, age 80, left hemisphere	200.2
2367	Female, age 91, left hemisphere	199.0
2324	Male, age 76, both hemispheres	193.1

Reticular pontine nucleus, caudal
nTPM: 224.3

2092	Male, age 76, both hemispheres	259.6
2457	Female, age 91, both hemispheres	241.0
2559	Male, age 74, both hemispheres	219.7
2332	Male, age 80, right hemisphere	176.9

Reticular pontine nucleus, oral
nTPM: 204.8

2361	Male, age 74, both hemispheres	211.8
2366	Female, age 91, both hemispheres	210.8
2167	Male, age 76, both hemispheres	207.8
1939	Male, age 80, both hemispheres	204.7
2012	Female, age 85, both hemispheres	188.7

Reticulotegmental nucleus
nTPM: 210.1

2452	Male, age 74, both hemispheres	242.9
2322	Female, age 91, both hemispheres	207.1
2325	Male, age 76, both hemispheres	195.8
2333	Male, age 80, both hemispheres	194.3

Spinal trigeminal nucleus, oral
nTPM: 200.4

2164	Male, age 80, both hemispheres	223.1
1978	Male, age 76, both hemispheres	198.9
2737	Female, age 85, both hemispheres	179.2

Subcoeruleus area
nTPM: 211.4

2451	Male, age 74, both hemispheres	251.5
2369	Female, age 85, left hemisphere	211.1
2089	Male, age 76, left hemisphere	210.6
1958	Male, age 80, both hemispheres	200.9
2323	Female, age 91, left hemisphere	182.7

Superior olive
nTPM: 213.8

2020	Male, age 76, both hemispheres	247.0
2561	Female, age 91, both hemispheres	220.8
1875	Female, age 85, both hemispheres	211.0
2364	Male, age 74, right hemisphere	203.0
2329	Male, age 80, right hemisphere	187.3

Ventral periolivary nuclei
nTPM: 219.0

2023	Male, age 76, both hemispheres	231.9
2165	Male, age 80, both hemispheres	217.9
2130	Female, age 85, both hemispheres	217.4
2794	Female, age 91, left hemisphere	208.9

Ventrolateral tegmental area, A5 NE cell group
nTPM: 213.8

2161	Male, age 80, both hemispheres	228.9
1959	Male, age 76, both hemispheres	228.4
2359	Male, age 61, both hemispheres	225.2
2449	Male, age 74, both hemispheres	201.8
2456	Female, age 91, both hemispheres	199.7
2840	Female, age 85, both hemispheres	198.8

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	42.8

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 42.8

FF:10182-103D2	60 years, female	49.1
FF:10165-103B3	76 years, female	36.4

Pons
Scaled Tags Per Million: 36.8

FF:10033-101E6

18-54 years, mixed

36.8

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	3.8

Macaque sample

Sample description

nTPM

Pons
nTPM: 3.8

Samples: 2

Max nTPM: 4.8
Min nTPM: 2.8

Sample A		4.8
Sample B		2.8

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	4.9

Pig sample

Sample description

nTPM

Pons
nTPM: 4.9

Samples: 3

Max nTPM: 7.8
Min nTPM: 0.9

Sample A	Female	0.9
Sample B	Female	7.8
Sample C	Male	5.9

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	257.7

Mouse sample

Sample description

nTPM

Pons
nTPM: 257.7

Samples: 4

Max nTPM: 261.2
Min nTPM: 253.3

Sample A		258.3
Sample B		261.2
Sample C		253.3
Sample D		257.9