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On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units. Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set. If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.
h
m
l
n
Glial cells:
Low
Neuronal cells:
High
RNA expressioni
A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas HPA, Genotype-Tissue Expression GTEx portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets. The mRNA expression levels in pig brain are based on RNA-seq data generated by the Human Protein Atlas, and for mouse brain HPA data and in situ hybridization generated by the Allen brain atlas dataset are reported.
Scroll down to view mRNA expression data in more detail.
HPA Brain:
195.9
nTPM
FANTOM5:
345.9
Scaled Tags Per Million
Pig:
82.3
nTPM
Mouse:
54.6
nTPM
Allen mouse:
11.6
Expression energy
CAUDATE - Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
Ascending and descending describe two types of gradient, based on difference in staining intensity between enterocytes in crypts and apical enterocytes.
Ascending - the staining intensity is stronger in apical enterocytes (towards the lumen) compared to enterocytes in the crypts (gland based)
Descending - the staining is weaker in apical enterocytes compared to enterocytes in crypts
Antibody HPA001814
Glial cells
Low
Neuronal cells
High
BASAL GANGLIA - HPA Brain RNA-seq
Max subtype nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
195.9
Sample id
Sample description
nTPM
Caudate nucleus nTPM: 191.7
1781
Male, age 74, unknown
255.9
1854
Male, age 80, left hemisphere
214.1
2481
Female, age 94, left hemisphere
204.0
2846
Female, age 79, unknown
199.0
2290
Female, age 72, unknown
193.3
2289
Male, age 61, right hemisphere
180.1
1857
Female, age 85, left hemisphere
166.3
2288
Male, age 75, left hemisphere
121.1
Globus pallidus, externus nTPM: 182.7
1996
Male, age 80, right hemisphere
272.3
2772
Female, age 79, unknown
229.4
2395
Male, age 75, both hemispheres
163.7
2567
Female, age 72, unknown
134.1
2646
Male, age 61, right hemisphere
114.2
Globus pallidus, internus nTPM: 166.3
2483
Female, age 94, right hemisphere
219.8
2037
Male, age 80, right hemisphere
215.6
2287
Male, age 75, right hemisphere
183.4
1818
Male, age 74, unknown
150.5
2778
Female, age 91, both hemispheres
148.9
2566
Female, age 72, unknown
137.9
2111
Female, age 85, right hemisphere
108.1
Nucleus accumbens nTPM: 167.4
2732
Male, age 80, right hemisphere
213.1
1856
Female, age 91, right hemisphere
189.0
2698
Female, age 72, unknown
178.6
1783
Male, age 74, unknown
174.8
1806
Female, age 85, left hemisphere
172.3
2391
Female, age 94, left hemisphere
157.3
2286
Male, age 75, left hemisphere
136.3
2824
Male, age 61, right hemisphere
117.9
Nucleus basalis of Meynert nTPM: 181.2
2393
Male, age 80, right hemisphere
238.1
2484
Female, age 94, left hemisphere
190.5
2821
Male, age 75, both hemispheres
174.6
2569
Male, age 61, both hemispheres
121.6
Nucleus of the diagonal band nTPM: 166.0
1812
Female, age 91, both hemispheres
199.8
2195
Female, age 85, both hemispheres
184.1
2775
Male, age 80, right hemisphere
159.6
1979
Male, age 74, unknown
157.9
2029
Male, age 61, right hemisphere
128.5
Putamen nTPM: 183.0
2482
Female, age 94, left hemisphere
300.6
2466
Female, age 79, unknown
227.3
1838
Male, age 80, right hemisphere
188.0
1937
Female, age 91, right hemisphere
174.6
2489
Female, age 72, unknown
166.3
1829
Male, age 74, unknown
137.1
2647
Male, age 75, left hemisphere
87.0
Septal nuclei nTPM: 195.9
2031
Female, age 72, unknown
235.0
1960
Male, age 74, unknown
218.7
2199
Male, age 80, right hemisphere
218.0
2059
Female, age 85, both hemispheres
211.3
2009
Female, age 91, both hemispheres
174.4
2629
Female, age 94, right hemisphere
164.2
2394
Male, age 61, left hemisphere
149.9
Stria terminalis, bed nucleus nTPM: 158.9
1974
Female, age 91, both hemispheres
186.4
2201
Male, age 74, unknown
148.8
2486
Female, age 94, both hemispheres
141.4
BASAL GANGLIA - FANTOM5 CAGEi
RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.
Max subtype Scaled Tags Per Millioni
Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.
RNA-seq data obtained from pig brain is reported as nTPM. Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Max subtype nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
82.3
Pig sample
Sample description
nTPM
Caudate nTPM: 71.1
Samples: 4
Max nTPM: 78.2
Min nTPM: 62.4
Sample A
Female
69.9
Sample B
Female
74.0
Sample C
Male
78.2
Sample D
Male
62.4
Putamen nTPM: 72.7
Samples: 4
Max nTPM: 103.2
Min nTPM: 59.7
Sample A
Female
63.2
Sample B
Female
59.7
Sample C
Male
103.2
Sample D
Male
64.7
Septum nTPM: 82.4
Samples: 4
Max nTPM: 92.5
Min nTPM: 65.6
Sample A
Female
92.5
Sample B
Female
80.3
Sample C
Male
91.1
Sample D
Male
65.6
Ventral pallidum nTPM: 76.8
Samples: 4
Max nTPM: 91.7
Min nTPM: 61.0
Sample A
Female
79.6
Sample B
Female
75.0
Sample C
Male
91.7
Sample D
Male
61.0
BASAL GANGLIA - Mouse RNA-seqi
RNA-seq data obtained from mouse brain is reported as nTPM. Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Max subtype nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
54.6
Mouse sample
Sample description
nTPM
Caudate putamen nTPM: 54.6
Samples: 4
Max nTPM: 57.2
Min nTPM: 52.3
Sample A
Male
54.7
Sample B
Male
52.3
Sample C
Female
57.2
Sample D
Female
54.2
Septum nTPM: 52.1
Samples: 4
Max nTPM: 54.9
Min nTPM: 49.2
Sample A
Male
54.5
Sample B
Male
49.7
Sample C
Female
49.2
Sample D
Female
54.9
Ventral forebrain nTPM: 53.7
Samples: 4
Max nTPM: 55.8
Min nTPM: 50.5
Sample A
Male
54.7
Sample B
Male
53.6
Sample C
Female
50.5
Sample D
Female
55.8
BASAL GANGLIA - Allen Mouse ISHi
In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.
Max subtype Expression energyi
Max subtype Expression energy is the value for the subtype with the largest average Expression energy across the subtype samples.
The Human Protein Atlas project is funded
