Brain tissue expression of SOD2 in hippocampal formation

HIPPOCAMPAL FORMATION - Expression summary

Protein expression
Hippocampusⁱ

Glial cells:	Low
Neuronal cells:	High

RNA expressionⁱ

HPA Brain:	181.8	nTPM
FANTOM5:	181.8	Scaled Tags Per Million

Macaque:	97.0	nTPM
Mouse:	43.3	nTPM
Rat:	57.0	nTPM
Pig:	75.1	nTPM

HIPPOCAMPUS - Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample. Ascending and descending describe two types of gradient, based on difference in staining intensity between enterocytes in crypts and apical enterocytes. Ascending - the staining intensity is stronger in apical enterocytes (towards the lumen) compared to enterocytes in the crypts (gland based) Descending - the staining is weaker in apical enterocytes compared to enterocytes in crypts

		Antibody HPA001814
Glial cells		Low
Neuronal cells		High

HIPPOCAMPAL FORMATION - PROTEINTALKS DB MS

Median intensity	56377

Sample

Intensity

Hippocampal formation_01

47330

Hippocampal formation_02

48184

Hippocampal formation_03

26552

Hippocampal formation_04

74365

Hippocampal formation_05

64570

Hippocampal formation_06

99782

HIPPOCAMPAL FORMATION - HPA Brain Stereo-seq

HIPPOCAMPAL FORMATION - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	181.8

Sample id

Sample description

nTPM

Dentate gyrus
nTPM: 181.8

2010	Male, age 76, both hemispheres	253.4
2528	Male, age 74, both hemispheres	188.5
2530	Female, age 94, left hemisphere	180.6
1927	Female, age 91, both hemispheres	163.9
2246	Female, age 85, both hemispheres	160.0
2531	Female, age 67, both hemispheres	144.4

Entorhinal gyrus
nTPM: 158.4

2686	Male, age 75, right hemisphere	186.4
2764	Male, age 80, right hemisphere	166.4
1938	Female, age 85, left hemisphere	166.0
2117	Female, age 91, right hemisphere	164.1
1787	Male, age 76, left hemisphere	151.3
2613	Female, age 94, left hemisphere	116.1

Hippocampus, CA1
nTPM: 167.4

2527	Male, age 74, both hemispheres	197.6
2082	Female, age 91, right hemisphere	169.5
2045	Male, age 76, both hemispheres	162.1
1873	Female, age 85, both hemispheres	160.7
2749	Male, age 80, left hemisphere	147.0

Hippocampus, CA2
nTPM: 176.8

2249	Male, age 74, both hemispheres	242.4
2437	Female, age 94, left hemisphere	175.6
1963	Male, age 80, left hemisphere	175.1
1940	Female, age 85, left hemisphere	170.7
2113	Female, age 91, right hemisphere	157.2
1892	Male, age 76, both hemispheres	139.6

Hippocampus, CA3
nTPM: 170.1

2436	Male, age 74, both hemispheres	271.4
1867	Male, age 76, both hemispheres	187.7
2137	Male, age 80, left hemisphere	160.5
1891	Female, age 85, both hemispheres	137.1
2861	Female, age 67, both hemispheres	136.2
2620	Female, age 94, left hemisphere	127.5

Parahippocampal cortex
nTPM: 158.8

2018	Male, age 76, both hemispheres	205.5
2250	Female, age 67, right hemisphere	194.1
2532	Female, age 72, left hemisphere	167.4
2245	Female, age 91, both hemispheres	166.8
1933	Female, age 85, both hemispheres	159.0
1990	Female, age 91, right hemisphere	155.7
1850	Male, age 80, both hemispheres	146.1
2692	Male, age 74, both hemispheres	136.9
2622	Female, age 67, right hemisphere	133.7
2693	Female, age 94, both hemispheres	123.0

Perirhinal gyrus
nTPM: 149.6

1847	Female, age 91, left hemisphere	180.7
1841	Female, age 85, right hemisphere	164.7
2521	Female, age 94, right hemisphere	155.5
1794	Male, age 80, right hemisphere	139.4
2848	Male, age 76, right hemisphere	107.8

Subiculum
nTPM: 161.9

2042	Male, age 76, both hemispheres	173.4
1977	Female, age 85, both hemispheres	166.6
1901	Male, age 80, both hemispheres	160.8
2438	Female, age 94, left hemisphere	159.7
2619	Male, age 74, both hemispheres	158.7
2729	Female, age 91, right hemisphere	152.1

HIPPOCAMPAL FORMATION - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	181.8

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Hippocampus
Scaled Tags Per Million: 181.8

FF:10169-103B7	60 years, female	217.0
FF:10153-102I9	76 years, female	146.6

HIPPOCAMPAL FORMATION - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	97.0

Macaque sample

Sample description

nTPM

Subiculum
nTPM: 80.7

Samples: 1

Max nTPM: 80.7
Min nTPM: 80.7

Sample A

80.7

Entorhinal cortex
nTPM: 97.0

Samples: 2

Max nTPM: 117.4
Min nTPM: 76.6

Sample A		117.4
Sample B		76.6

Hippocampal formation
nTPM: 96.1

Samples: 4

Max nTPM: 115.3
Min nTPM: 81.2

Sample A		90.6
Sample B		81.2
Sample C		97.4
Sample D		115.3

HIPPOCAMPAL FORMATION - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	75.1

Pig sample

Sample description

nTPM

Subiculum
nTPM: 75.2

Samples: 4

Max nTPM: 102.0
Min nTPM: 60.5

Sample A	Female	102.0
Sample B	Female	66.5
Sample C	Male	71.6
Sample D	Male	60.5

Dorsal hippocampus
nTPM: 68.0

Samples: 4

Max nTPM: 79.9
Min nTPM: 54.2

Sample A	Female	79.9
Sample B	Female	69.0
Sample C	Male	68.8
Sample D	Male	54.2

Entorhinal cortex
nTPM: 67.8

Samples: 4

Max nTPM: 80.1
Min nTPM: 55.8

Sample A	Female	65.4
Sample B	Female	80.1
Sample C	Male	69.7
Sample D	Male	55.8

Ventral hippocampus
nTPM: 69.9

Samples: 4

Max nTPM: 84.7
Min nTPM: 57.8

Sample A	Female	75.8
Sample B	Female	57.8
Sample C	Male	84.7
Sample D	Male	61.4

HIPPOCAMPAL FORMATION - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	43.3

Mouse sample

Sample description

nTPM

Entorhinal cortex
nTPM: 43.3

Samples: 4

Max nTPM: 49.0
Min nTPM: 38.5

Sample A		42.1
Sample B		43.5
Sample C		38.5
Sample D		49.0

Hippocampal formation
nTPM: 34.2

Samples: 4

Max nTPM: 38.8
Min nTPM: 31.1

Sample A		31.7
Sample B		31.1
Sample C		35.3
Sample D		38.8

HIPPOCAMPAL FORMATION - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	57.0

Rat sample

Sample description

nTPM

Entorhinal cortex
nTPM: 55.0

Samples: 4

Max nTPM: 59.6
Min nTPM: 51.2

Sample A		59.6
Sample A		56.8
Sample A		51.2
Sample B		52.3

Ventral hippocampus
nTPM: 57.0

Samples: 4

Max nTPM: 60.7
Min nTPM: 51.5

Sample A		58.5
Sample A		51.5
Sample A		57.4
Sample A		60.7