ABCB5

GENERAL INFORMATION

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Gene name

ABCB5

Gene description

ATP-binding cassette, sub-family B (MDR/TAP), member 5

Protein class

Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (gallbladder)
GTEx:Tissue enhanced (breast)

Protein evidence

Evidence at protein level

Protein localization

A majority of normal tissues showed weak to moderate cytoplasmic staining often combined with a granular pattern. Strong staining was observed in glandular cells in prostate, endometrium, gall bladder and thyroid glad as well as subsets of renal tubule. Lung alveolar cells and most cells in CNS and lymphoid tissues were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA026975
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (gallbladder)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (breast)

Organ

Expression



GENE INFORMATION

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Gene name

ABCB5 (HGNC Symbol)

Synonyms

ABCB5alpha, ABCB5beta, EST422562

Description

ATP-binding cassette, sub-family B (MDR/TAP), member 5 (HGNC Symbol)

Entrez gene summary

ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]

Chromosome

7

Cytoband

p21.1

Chromosome location (bp)

20615207 - 20777038

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000004846 (version 78.38)

Entrez gene

340273

UniProt

Q2M3G0 (UniProt - Evidence at protein level)

neXtProt

NX_Q2M3G0

Antibodypedia

ABCB5 antibodies


PROTEIN BROWSER

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ENST00000258738
 
ENST00000404938
 
ENST00000406935
 
ENST00000443026
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCB5-001 ENSP00000258738
ENST00000258738
Q2M3G0
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Show » Show » 812 89.8 No 5
ABCB5-002 ENSP00000383899
ENST00000406935
Q2M3G0
Show all »
Show » Show » 126 14.1 No 0
ABCB5-003 ENSP00000406730
ENST00000443026
Q2M3G0
Show all »
Show » Show » 131 14.7 No 0
ABCB5-004 ENSP00000384881
ENST00000404938
Q2M3G0
Show all »
Show » Show » 1257 138.6 No >9