CACNA1G

GENERAL INFORMATION

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Gene name

CACNA1G

Gene description

Calcium channel, voltage-dependent, T type, alpha 1G subunit

Protein class

FDA approved drug targets
Plasma proteins
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

28
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (cerebral cortex, endometrium)
GTEx:Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression in CNS. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 1 antibody.
HPA004714
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (cerebral cortex, endometrium)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebellum)

Organ

Expression



GENE INFORMATION

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Gene name

CACNA1G (HGNC Symbol)

Synonyms

Cav3.1, NBR13

Description

Calcium channel, voltage-dependent, T type, alpha 1G subunit (HGNC Symbol)

Entrez gene summary

Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011]

Chromosome

17

Cytoband

q21.33

Chromosome location (bp)

50561068 - 50627474

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000006283 (version 78.38)

Entrez gene

8913

UniProt

O43497 (UniProt - Evidence at transcript level)

neXtProt

NX_O43497

Antibodypedia

CACNA1G antibodies


PROTEIN BROWSER

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 « 
 
ENST00000352832
 
ENST00000354983
 
ENST00000358244
 
ENST00000359106
 
ENST00000360761
 
ENST00000416767
 
ENST00000429973
 
ENST00000442258
 
ENST00000502264
 
ENST00000503485
 
ENST00000505165
 
ENST00000506520
 
ENST00000507336
 
ENST00000507510
 
ENST00000507609
 
ENST00000507896
 
ENST00000510115
 
ENST00000510366
 
ENST00000512389
 
ENST00000513689
 
ENST00000513964
 
ENST00000514079
 
ENST00000514181
 
ENST00000514717
 
ENST00000515165
 
ENST00000515411
 
ENST00000515765
 
ENST00000570567
 
 » 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CACNA1G-001 ENSP00000339302
ENST00000352832
O43497
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Show » Show » 2250 249.3 No >9
CACNA1G-002 ENSP00000425451
ENST00000513964
O43497
Show all »
Show » Show » 2239 247.8 No >9
CACNA1G-003 ENSP00000422407
ENST00000514717
O43497
Show all »
Show » Show » 2227 246.2 No >9
CACNA1G-004 ENSP00000426814
ENST00000510366
O43497
Show all »
Show » Show » 2232 247 No >9
CACNA1G-005 ENSP00000427238
ENST00000503485
O43497
Show all »
Show » Show » 2250 248.7 No >9
CACNA1G-007 ENSP00000414388
ENST00000429973
O43497
Show all »
Show » Show » 2266 251 No >9
CACNA1G-008 ENSP00000353990
ENST00000360761
O43497
Show all »
Show » Show » 2261 250.2 No >9
CACNA1G-009 ENSP00000423112
ENST00000507510
O43497
Show all »
Show » Show » 2332 257.7 No >9
CACNA1G-011 ENSP00000420918
ENST00000507336
O43497
Show all »
Show » Show » 2366 261.6 No >9
CACNA1G-013 ENSP00000352011
ENST00000359106
O43497
Show all »
Show » Show » 2377 262.5 No >9
CACNA1G-015 ENSP00000426172
ENST00000513689
O43497
Show all »
Show » Show » 2287 252.8 No >9
CACNA1G-016 ENSP00000423045
ENST00000507609
O43497
Show all »
Show » Show » 2277 251.9 No >9
CACNA1G-018 ENSP00000427173
ENST00000510115
O43497
Show all »
Show » Show » 2298 254.4 No >9
CACNA1G-019 ENSP00000409759
ENST00000442258
O43497
Show all »
Show » Show » 2243 248.5 No >9
CACNA1G-020 ENSP00000426098
ENST00000515165
O43497
Show all »
Show » Show » 2284 252.7 No >9
CACNA1G-021 ENSP00000425698
ENST00000514181
O43497
Show all »
Show » Show » 2259 250.2 No >9
CACNA1G-023 ENSP00000392390
ENST00000416767
Show » Show » 1555 171.4 No >9
CACNA1G-024 ENSP00000426261
ENST00000512389
O43497
Show all »
Show » Show » 2273 251.8 No >9
CACNA1G-025 ENSP00000426232
ENST00000515765
O43497
Show all »
Show » Show » 2321 256.8 No >9
CACNA1G-026 ENSP00000423317
ENST00000514079
O43497
Show all »
Show » Show » 2291 253.5 No >9
CACNA1G-027 ENSP00000350979
ENST00000358244
O43497
Show all »
Show » Show » 2171 240.9 No >9
CACNA1G-028 ENSP00000421518
ENST00000507896
O43497
Show all »
Show » Show » 2194 243.4 No >9
CACNA1G-029 ENSP00000427697
ENST00000506520
H0YAN0
Show all »
Show » Show » 337 37.5 No 4
CACNA1G-031 ENSP00000425522
ENST00000502264
O43497
Show all »
Show » Show » 2306 255 No >9
CACNA1G-032 ENSP00000422268
ENST00000505165
O43497
Show all »
Show » Show » 2205 244.2 No >9
CACNA1G-034 ENSP00000423155
ENST00000515411
O43497
Show all »
Show » Show » 2314 256 No >9
CACNA1G-035 ENSP00000459988
ENST00000570567
I3L2W8
Show all »
Show » Show » 277 31.5 No 5
CACNA1G-201 ENSP00000347078
ENST00000354983
O43497
Show all »
Show » Show » 2343 259.1 No >9