ROS1

GENERAL INFORMATION

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Gene name

ROS1

Gene description

ROS proto-oncogene 1 , receptor tyrosine kinase

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (lung)
GTEx:Tissue enriched (lung)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression in lung. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Pending external verification. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 1 antibody.
HPA049098
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Rectum

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (lung)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (lung)

Organ

Expression



GENE INFORMATION

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Gene name

ROS1 (HGNC Symbol)

Synonyms

c-ros-1, MCF3, ROS

Description

ROS proto-oncogene 1 , receptor tyrosine kinase (HGNC Symbol)

Entrez gene summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

q22.1

Chromosome location (bp)

117288300 - 117425855

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000047936 (version 78.38)

Entrez gene

6098

UniProt

P08922 (UniProt - Evidence at protein level)

neXtProt

NX_P08922

Antibodypedia

ROS1 antibodies


PROTEIN BROWSER

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ENST00000368507
 
ENST00000368508
 
ENST00000403284
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ROS1-001 ENSP00000357494
ENST00000368508
P08922
Show all »
Show » Show » 2347 263.9 Yes 1
ROS1-002 ENSP00000357493
ENST00000368507
Q5H8Y1
Show all »
Show » Show » 2341 263.3 Yes 1
ROS1-003 ENSP00000384647
ENST00000403284
H0Y3T9
Show all »
Show » Show » 97 11.1 No 0