TRPM7

GENERAL INFORMATION

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Gene name

TRPM7

Gene description

Transient receptor potential cation channel, subfamily M, member 7

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

Intracellular,Membrane

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most of the normal tissues displayed moderate to strong cytoplasmic positivity in a granular pattern. Alveolar cells, cells in glomeruli, decidual cells, glial cells and smooth muscle cells were negative or weakly stained.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA035523
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

TRPM7 (HGNC Symbol)

Synonyms

CHAK1, LTRPC7, TRP-PLIK

Description

Transient receptor potential cation channel, subfamily M, member 7 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

15

Cytoband

q21.2

Chromosome location (bp)

50552473 - 50686815

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000092439 (version 78.38)

Entrez gene

54822

UniProt

Q96QT4 (UniProt - Evidence at protein level)

neXtProt

NX_Q96QT4

Antibodypedia

TRPM7 antibodies


PROTEIN BROWSER

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ENST00000313478
 
ENST00000560638
 
ENST00000560955
 
ENST00000561267
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRPM7-001 ENSP00000320239
ENST00000313478
Q96QT4
Show all »
Show » Show » 1865 212.7 No 6
TRPM7-002 ENSP00000453277
ENST00000560955
H0YLN8
Show all »
Show » Show » 1864 212.6 No 6
TRPM7-004 ENSP00000452873
ENST00000560638
Q96QT4
Show all »
Show » Show » 535 62.7 No 5
TRPM7-010 ENSP00000454066
ENST00000561267
Show » Show » 234 26.8 No 0