CHGA

GENERAL INFORMATION

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Gene name

CHGA

Gene description

Chromogranin A (parathyroid secretory protein 1)

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (adrenal gland)
GTEx:Tissue enhanced (adrenal gland, cerebral cortex, stomach)

Protein evidence

Evidence at protein level

Protein localization

Selective cytoplasmic expression in neuroendocrine cells.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 5 antibodies.
HPA017369 , CAB000023 , CAB040544 , CAB055506 , CAB058688
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (adrenal gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (adrenal gland, cerebral cortex, stomach)

Organ

Expression



GENE INFORMATION

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Gene name

CHGA

Synonyms

Description

Chromogranin A (parathyroid secretory protein 1) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Chromosome

14

Cytoband

q32.12

Chromosome location (bp)

92923080 - 92935293

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100604 (version 78.38)

Entrez gene

1113

UniProt

P10645 (UniProt - Evidence at protein level)

neXtProt

NX_P10645

Antibodypedia

CHGA antibodies


PROTEIN BROWSER

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ENST00000216492
 
ENST00000334654
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHGA-001 ENSP00000216492
ENST00000216492
P10645
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Show » Show » 457 50.7 Yes 0
CHGA-003 ENSP00000334023
ENST00000334654
G5E968
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Show » Show » 306 34.3 Yes 0