BLNK

GENERAL INFORMATION

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Gene name

BLNK

Gene description

B-cell linker

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein localization

Distinct cytoplasmic expression in subsets of lymphoid cells. Lower expression observed in several other tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 4 antibodies.
HPA038309 , HPA038310 , CAB009333 , CAB016291
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (spleen)

Organ

Expression



GENE INFORMATION

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Gene name

BLNK (HGNC Symbol)

Synonyms

BASH, bca, BLNK-s, Ly57, SLP-65, SLP65

Description

B-cell linker (HGNC Symbol)

Entrez gene summary

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

10

Cytoband

q24.1

Chromosome location (bp)

96191702 - 96271587

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000095585 (version 78.38)

Entrez gene

29760

UniProt

Q8WV28 (UniProt - Evidence at protein level)

neXtProt

NX_Q8WV28

Antibodypedia

BLNK antibodies


PROTEIN BROWSER

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ENST00000224337
 
ENST00000371176
 
ENST00000413476
 
ENST00000427367
 
ENST00000495266
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BLNK-001 ENSP00000224337
ENST00000224337
Q8WV28
Show all »
Show » Show » 456 50.5 No 0
BLNK-002 ENSP00000360218
ENST00000371176
Q8WV28
Show all »
Show » Show » 433 48.2 No 0
BLNK-003 ENSP00000465741
ENST00000495266
K7EKR2
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Show » 65 7.4 No 0
BLNK-201 ENSP00000397487
ENST00000413476
Q8WV28
Show all »
Show » Show » 404 44.5 No 0
BLNK-202 ENSP00000391924
ENST00000427367
Q2MD59
Show all »
Show » 299 33 No 0