PSMA7

GENERAL INFORMATION

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Gene name

PSMA7

Gene description

Proteasome (prosome, macropain) subunit, alpha type, 7

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Strong cytoplasmic and nuclear positivity was observed in stomach. Hepatocytes, Purkinje cells, kidney, oral mucosa and glandular cells of uterus displayed moderate nuclear staining. Remaining normal tissues were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA047266
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PSMA7 (HGNC Symbol)

Synonyms

C6, HSPC, RC6-1, XAPC7

Description

Proteasome (prosome, macropain) subunit, alpha type, 7 (HGNC Symbol)

Entrez gene summary

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012]

Chromosome

20

Cytoband

q13.33

Chromosome location (bp)

62136735 - 62143440

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101182 (version 78.38)

Entrez gene

5688

UniProt

O14818 (UniProt - Evidence at protein level)

neXtProt

NX_O14818

Antibodypedia

PSMA7 antibodies


PROTEIN BROWSER

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ENST00000370858
 
ENST00000370861
 
ENST00000370873
 
ENST00000442551
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMA7-001 ENSP00000359910
ENST00000370873
O14818
Show all »
Show » Show » 248 27.9 No 0
PSMA7-002 ENSP00000359898
ENST00000370861
O14818
Show all »
Show » Show » 178 20.2 No 0
PSMA7-005 ENSP00000359895
ENST00000370858
O14818
Show all »
Show » Show » 149 16.1 No 0
PSMA7-006 ENSP00000397047
ENST00000442551
Show » Show » 187 21.1 No 0