SH2D1B

GENERAL INFORMATION

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Gene name

SH2D1B

Gene description

SH2 domain containing 1B

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (spleen)
GTEx:Tissue enhanced (skeletal muscle, spleen)

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues displayed moderate cytoplasmic and membranous positivity. Subset cells of gastro intestinal tract and glandular cells of uterine showed strong positivity. Liver, trophoblastic cells, prostate, lymphoid tissues and glial cells were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA054791
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (spleen)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (skeletal muscle, spleen)

Organ

Expression



GENE INFORMATION

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Gene name

SH2D1B (HGNC Symbol)

Synonyms

EAT2

Description

SH2 domain containing 1B (HGNC Symbol)

Entrez gene summary

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008]

Chromosome

1

Cytoband

q23.3

Chromosome location (bp)

162395266 - 162412138

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198574 (version 78.38)

Entrez gene

117157

UniProt

O14796 (UniProt - Evidence at protein level)

neXtProt

NX_O14796

Antibodypedia

SH2D1B antibodies


PROTEIN BROWSER

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ENST00000367929
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SH2D1B-001 ENSP00000356906
ENST00000367929
O14796
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