DLX1

GENERAL INFORMATION

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Gene name

DLX1

Gene description

Distal-less homeobox 1

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (adrenal gland, cerebral cortex)
GTEx:Group enriched (cerebral cortex, hippocampus, thyroid gland)

Protein evidence

Evidence at transcript level

Protein localization

The acrosomal cap of spermatids were strongly stained. A subset of Purkinje cells showed moderate nucleolar staining while renal tubules, ovarian follicle cells and smooth muscle displayed moderate cytoplasmic positivity. The gastrointestinal tract exhibited weak to moderate cytoplasmic and membranous staining. Remaining normal tissues were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA045884
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (adrenal gland, cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cerebral cortex, hippocampus, thyroid gland)

Organ

Expression



GENE INFORMATION

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Gene name

DLX1

Synonyms

Description

Distal-less homeobox 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q31.1

Chromosome location (bp)

172084740 - 172089677

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000144355 (version 78.38)

Entrez gene

1745

UniProt

P56177 (UniProt - Evidence at transcript level)

neXtProt

NX_P56177

Antibodypedia

DLX1 antibodies


PROTEIN BROWSER

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ENST00000341900
 
ENST00000361609
 
ENST00000361725
 
ENST00000469444
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DLX1-001 ENSP00000354478
ENST00000361725
P56177
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Show » Show » 255 27.3 No 0
DLX1-002 ENSP00000341786
ENST00000341900
P56177
Show all »
Show » Show » 129 13.5 No 0
DLX1-004 ENSP00000448827
ENST00000469444
F8VXJ2
Show all »
Show » Show » 187 20.5 No 0
DLX1-006 ENSP00000354865
ENST00000361609
J3KP55
Show all »
Show » Show » 171 18.5 No 0