UPF2

GENERAL INFORMATION

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Gene name

UPF2

Gene description

UPF2 regulator of nonsense transcripts homolog (yeast)

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

UPF2 (HGNC Symbol)

Synonyms

DKFZP434D222, KIAA1408, RENT2, smg-3

Description

UPF2 regulator of nonsense transcripts homolog (yeast) (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

p14

Chromosome location (bp)

11920022 - 12043170

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151461 (version 78.38)

Entrez gene

26019

UniProt

Q9HAU5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HAU5

Antibodypedia

UPF2 antibodies


PROTEIN BROWSER

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ENST00000356352
 
ENST00000357604
 
ENST00000397053
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UPF2-001 ENSP00000348708
ENST00000356352
Q9HAU5
Show all »
Show » Show » 1272 147.8 No 0
UPF2-002 ENSP00000350221
ENST00000357604
Q9HAU5
Show all »
Show » Show » 1272 147.8 No 0
UPF2-201 ENSP00000380244
ENST00000397053
Q9HAU5
Show all »
Show » Show » 1272 147.8 No 0