ALPP

GENERAL INFORMATION

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Gene name

ALPP

Gene description

Alkaline phosphatase, placental

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (placenta)
GTEx:Group enriched (cervix, uterine, fallopian tube, lung)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and membranous expression in placental trophoblasts.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Data reliability

Supportive based on 4 antibodies.
HPA038764 , HPA038765 , HPA051699 , CAB026327
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (placenta)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cervix, uterine, fallopian tube, lung)

Organ

Expression



GENE INFORMATION

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Gene name

ALPP

Synonyms

Description

Alkaline phosphatase, placental (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]

Chromosome

2

Cytoband

q37.1

Chromosome location (bp)

232378534 - 232382889

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163283 (version 78.38)

Entrez gene

250

UniProt

P05187 (UniProt - Evidence at protein level)

neXtProt

NX_P05187

Antibodypedia

ALPP antibodies


PROTEIN BROWSER

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ENST00000392027
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ALPP-001 ENSP00000375881
ENST00000392027
P05187
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