CHRM1

GENERAL INFORMATION

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Gene name

CHRM1

Gene description

Cholinergic receptor, muscarinic 1

Protein class

FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (cerebral cortex, prostate, salivary gland)
GTEx:Group enriched (cerebral cortex, hippocampus, prostate, salivary gland)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in pyramidal neurons and Purkinje cells.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. External characterization data supports antibody staining.

Data reliability

Supportive based on 1 antibody.
HPA014101
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (cerebral cortex, prostate, salivary gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cerebral cortex, hippocampus, prostate, salivary gland)

Organ

Expression



GENE INFORMATION

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Gene name

CHRM1

Synonyms

Description

Cholinergic receptor, muscarinic 1 (HGNC Symbol)

Entrez gene summary

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q12.3

Chromosome location (bp)

62908679 - 62921807

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168539 (version 78.38)

Entrez gene

1128

UniProt

P11229 (UniProt - Evidence at protein level)

neXtProt

NX_P11229

Antibodypedia

CHRM1 antibodies


PROTEIN BROWSER

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ENST00000306960
 
ENST00000536524
 
ENST00000543973
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHRM1-001 ENSP00000306490
ENST00000306960
P11229
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Show » Show » 460 51.4 No 7
CHRM1-002 ENSP00000441188
ENST00000543973
P11229
Show all »
Show » Show » 454 50.7 No 7
CHRM1-003 ENSP00000444482
ENST00000536524
F5GZF8
Show all »
Show » Show » 134 14.6 No 3