DPP10

GENERAL INFORMATION

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Gene name

DPP10

Gene description

Dipeptidyl-peptidase 10 (non-functional)

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (adrenal gland, cerebral cortex)
GTEx:Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA048767
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (adrenal gland, cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebral cortex)

Organ

Expression



GENE INFORMATION

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Gene name

DPP10 (HGNC Symbol)

Synonyms

DPRP3

Description

Dipeptidyl-peptidase 10 (non-functional) (HGNC Symbol)

Entrez gene summary

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q14.1

Chromosome location (bp)

114442299 - 115845752

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000175497 (version 78.38)

Entrez gene

57628

UniProt

Q8N608 (UniProt - Evidence at protein level)

neXtProt

NX_Q8N608

Antibodypedia

DPP10 antibodies


PROTEIN BROWSER

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ENST00000310323
 
ENST00000393146
 
ENST00000393147
 
ENST00000409163
 
ENST00000410059
 
ENST00000419287
 
ENST00000436732
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DPP10-001 ENSP00000386565
ENST00000410059
Q8N608
Show all »
Show » Show » 796 90.9 No 1
DPP10-002 ENSP00000387038
ENST00000409163
Q8N608
Show all »
Show » Show » 746 85.5 No 0
DPP10-005 ENSP00000309066
ENST00000310323
Q8N608
Show all »
Show » Show » 789 90.1 No 1
DPP10-007 ENSP00000376855
ENST00000393147
Q8N608
Show all »
Show » Show » 800 91.1 No 1
DPP10-008 ENSP00000391092
ENST00000436732
C9J4M8
Show all »
Show » Show » 60 7 No 0
DPP10-009 ENSP00000376854
ENST00000393146
J3KPP1
Show all »
Show » Show » 259 29.6 No 1
DPP10-011 ENSP00000402499
ENST00000419287
J3KQK8
Show all »
Show » Show » 97 11.1 No 0