GAK

GENERAL INFORMATION

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Gene name

GAK

Gene description

Cyclin G associated kinase

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 3 antibodies.
HPA027405 , HPA027459 , HPA027463
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

GAK (HGNC Symbol)

Synonyms

DNAJC26

Description

Cyclin G associated kinase (HGNC Symbol)

Entrez gene summary

In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Chromosome

4

Cytoband

p16.3

Chromosome location (bp)

849276 - 932373

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000178950 (version 78.38)

Entrez gene

2580

UniProt

O14976 (UniProt - Evidence at protein level)

neXtProt

NX_O14976

Antibodypedia

GAK antibodies


PROTEIN BROWSER

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ENST00000314167
 
ENST00000502656
 
ENST00000510799
 
ENST00000511163
 
ENST00000511229
 
ENST00000511980
 
ENST00000618573
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GAK-001 ENSP00000314499
ENST00000314167
O14976
Show all »
Show » Show » 1311 143.2 No 0
GAK-002 ENSP00000421361
ENST00000511163
O14976
Show all »
Show » Show » 1232 134.5 No 0
GAK-010 ENSP00000426062
ENST00000510799
Show » 255 25.4 No 0
GAK-011 ENSP00000421049
ENST00000511980
Show » 467 49 No 0
GAK-015 ENSP00000422391
ENST00000511229
D6RC24
Show all »
Show » Show » 70 7.8 No 0
GAK-020 ENSP00000424701
ENST00000502656
D6RAW3
Show all »
Show » Show » 138 15.2 No 0
GAK-201 ENSP00000484475
ENST00000618573
Show » 416 44 No 0