HLA-DQB1

GENERAL INFORMATION

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Gene name

HLA-DQB1

Gene description

Major histocompatibility complex, class II, DQ beta 1

Protein class

Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (lymph node)
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression primarily in immune cells.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA013667
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (lymph node)

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

HLA-DQB1 (HGNC Symbol)

Synonyms

CELIAC1, HLA-DQB, IDDM1

Description

Major histocompatibility complex, class II, DQ beta 1 (HGNC Symbol)

Entrez gene summary

HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Chromosome

6

Cytoband

p21.32

Chromosome location (bp)

32659467 - 32668383

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000179344 (version 78.38)

Entrez gene

3119

UniProt

neXtProt

Antibodypedia

HLA-DQB1 antibodies


PROTEIN BROWSER

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ENST00000374943
 
ENST00000399079
 
ENST00000399082
 
ENST00000399084
 
ENST00000434651
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HLA-DQB1-001 ENSP00000407332
ENST00000434651
Q5Y7D6
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Show » Show » 261 29.8 Yes 1
HLA-DQB1-002 ENSP00000364080
ENST00000374943
Q5SU54
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Show » Show » 269 30.5 Yes 1
HLA-DQB1-003 ENSP00000382034
ENST00000399084
Q5Y7D6
Show all »
Show » Show » 261 29.8 Yes 1
HLA-DQB1-004 ENSP00000382029
ENST00000399079
A2AAZ0
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Show » Show » 224 26 Yes 0
HLA-DQB1-007 ENSP00000382032
ENST00000399082
A2AAY8
Show all »
Show » Show » 134 15.2 Yes 0