NPM1

GENERAL INFORMATION

? »

Gene name

NPM1

Gene description

Nucleophosmin (nucleolar phosphoprotein B23, numatrin)

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA011384 , CAB012983
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

NPM1 (HGNC Symbol)

Synonyms

B23, NPM

Description

Nucleophosmin (nucleolar phosphoprotein B23, numatrin) (HGNC Symbol)

Entrez gene summary

This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]

Chromosome

5

Cytoband

q35.1

Chromosome location (bp)

171387116 - 171411137

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000181163 (version 78.38)

Entrez gene

4869

UniProt

P06748 (UniProt - Evidence at protein level)

neXtProt

NX_P06748

Antibodypedia

NPM1 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000296930
 
ENST00000351986
 
ENST00000393820
 
ENST00000517671
 
ENST00000521672
 
ENST00000523622
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NPM1-001 ENSP00000296930
ENST00000296930
P06748
Show all »
Show » Show » 294 32.6 No 0
NPM1-002 ENSP00000341168
ENST00000351986
P06748
Show all »
Show » Show » 265 29.5 No 0
NPM1-003 ENSP00000377408
ENST00000393820
P06748
Show all »
Show » Show » 259 28.4 No 0
NPM1-004 ENSP00000428755
ENST00000517671
P06748
Show all »
Show » Show » 294 32.6 No 0
NPM1-005 ENSP00000429485
ENST00000521672
E5RI98
Show all »
Show » Show » 111 11.9 No 0
NPM1-007 ENSP00000428647
ENST00000523622
E5RGW4
Show all »
Show » Show » 59 6.9 No 0