ATL1

GENERAL INFORMATION

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Gene name

ATL1

Gene description

Atlastin GTPase 1

Protein class

Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (cerebral cortex)
GTEx:Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression, mainly in CNS.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA027550
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebral cortex)

Organ

Expression



GENE INFORMATION

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Gene name

ATL1 (HGNC Symbol)

Synonyms

AD-FSP, FSP1, SPG3, SPG3A

Description

Atlastin GTPase 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q22.1

Chromosome location (bp)

50532509 - 50633068

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198513 (version 78.38)

Entrez gene

51062

UniProt

Q8WXF7 (UniProt - Evidence at protein level)

neXtProt

NX_Q8WXF7

Antibodypedia

ATL1 antibodies


PROTEIN BROWSER

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ENST00000358385
 
ENST00000441560
 
ENST00000553509
 
ENST00000554886
 
ENST00000555960
 
ENST00000557735
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATL1-001 ENSP00000351155
ENST00000358385
Q8WXF7
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Show » Show » 558 63.5 No 2
ATL1-002 ENSP00000413675
ENST00000441560
Q8WXF7
Show all »
Show » Show » 553 63.1 No 2
ATL1-005 ENSP00000452506
ENST00000555960
G3V5T4
Show all »
Show » Show » 100 11.6 No 0
ATL1-006 ENSP00000450989
ENST00000553509
G3V321
Show all »
Show » 29 3.5 No 0
ATL1-008 ENSP00000452074
ENST00000554886
G3V4Y8
Show all »
Show » Show » 75 8.7 No 0
ATL1-012 ENSP00000451015
ENST00000557735
G3V334
Show all »
Show » Show » 47 5.6 No 0