THE HUMAN PROTEIN ATLAS BLOG

The housekeeping proteome

2016-06-28
Cytoskeleton Gene expression Housekeeping Metabolism Proteome RNA

Immunohistochemical staining showing the nuclear localization of the polymerase protein POLR2A responsible for synthesizing messenger RNA in eukaryotes.

A large number of proteins are needed in all cells throughout the human body. These proteins are sometimes called housekeeping proteins, suggesting that their expression is crucial for the maintenance of basic functionality of all normally functioning cells.

A transcriptomics analysis shows that about 9,000 genes are expressed in all tissues and are therefore expected to fulfill these tasks, such as gene expression, metabolism, and cell structure.

As for gene expression, it is easily understood that every cell must have proteins that are involved in the genetic machinery of translating DNA to functional proteins, like RNA polymerases and ribosomal proteins...Read more