Brain tissue expression of MT3 in pons - The Human Protein Atlas

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	1158.3	nTPM
FANTOM5:	620.6	Scaled Tags Per Million

Rat:	760.9	nTPM
Pig:	1520.5	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	1158.3

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 993.6

1984	Male, age 76, both hemispheres	1021.1
2188	Female, age 91, both hemispheres	1001.4
2301	Female, age 85, both hemispheres	979.6
2090	Male, age 80, both hemispheres	972.4

Dorsal cochlear nucleus
nTPM: 1013.9

2370	Male, age 61, both hemispheres	1152.3
2058	Male, age 76, both hemispheres	1081.2
2802	Male, age 74, right hemisphere	1059.4
2187	Female, age 91, both hemispheres	962.2
2378	Male, age 80, both hemispheres	814.5

Dorsal tegmental nucleus
nTPM: 1024.4

2083	Male, age 80, both hemispheres	1437.7
1936	Male, age 76, left hemisphere	1177.3
2326	Male, age 74, both hemispheres	960.2
2358	Male, age 61, both hemispheres	522.2

Dorsolateral tegmental area
nTPM: 1065.7

2751	Female, age 85, both hemispheres	1357.0
2654	Male, age 80, both hemispheres	1271.0
2141	Male, age 76, both hemispheres	983.6
2360	Male, age 74, both hemispheres	925.4
2337	Male, age 61, both hemispheres	791.3

Kolliker-Fuse nucleus
nTPM: 1114.9

2315	Male, age 76, right hemisphere	1271.5
2163	Male, age 80, both hemispheres	1165.4
2793	Female, age 91, left hemisphere	907.7

Lateral lemniscal nuclei
nTPM: 842.6

2169	Male, age 76, both hemispheres	1007.6
2746	Female, age 85, left hemisphere	896.1
2320	Female, age 91, left hemisphere	807.8
2036	Male, age 80, both hemispheres	791.9
2453	Male, age 74, right hemisphere	709.4

Lateral parabrachial nucleus
nTPM: 1050.5

2139	Female, age 85, right hemisphere	1230.7
2792	Male, age 76, both hemispheres	1180.5
2013	Male, age 80, both hemispheres	1029.5
2790	Male, age 61, both hemispheres	761.2

Lateral vestibular nucleus
nTPM: 1158.3

2184	Male, age 76, both hemispheres	1255.8
2311	Male, age 80, both hemispheres	1060.7

Locus coeruleus
nTPM: 997.5

2317	Female, age 72, unknown	1219.2
2014	Male, age 55, unknown	1106.5
2123	Female, age 91, both hemispheres	1023.9
2162	Male, age 80, both hemispheres	995.8
1980	Male, age 76, both hemispheres	977.3
2788	Male, age 74, unknown	893.9
2720	Male, age 74, both hemispheres	765.9

Medial parabrachial nucleus
nTPM: 1096.5

2463	Female, age 85, right hemisphere	1293.0
2170	Female, age 91, both hemispheres	1236.6
2156	Male, age 61, both hemispheres	1081.9
2786	Male, age 76, both hemispheres	1031.1
2854	Male, age 80, both hemispheres	839.7

Medial periolivary nuclei
nTPM: 859.3

2063	Male, age 76, both hemispheres	1067.1
2791	Male, age 74, right hemisphere	911.3
2171	Female, age 85, both hemispheres	814.0
2081	Male, age 80, both hemispheres	773.7
2458	Female, age 91, both hemispheres	730.3

Motor facial nucleus
nTPM: 872.7

2062	Male, age 76, both hemispheres	1255.8
2126	Male, age 61, both hemispheres	957.2
2795	Female, age 91, both hemispheres	929.2
2365	Male, age 74, right hemisphere	797.1
2327	Male, age 80, both hemispheres	671.6
2697	Female, age 85, both hemispheres	625.5

Motor trigeminal nucleus
nTPM: 907.4

2309	Male, age 76, both hemispheres	1104.0
2079	Male, age 80, both hemispheres	987.3
2335	Male, age 61, both hemispheres	901.9
2321	Female, age 91, both hemispheres	782.3
2560	Male, age 74, both hemispheres	761.4

Nuclei of the trapezoid body
nTPM: 982.6

1983	Male, age 76, both hemispheres	1310.8
2159	Male, age 61, both hemispheres	951.1
2735	Female, age 85, both hemispheres	894.8
2368	Female, age 91, both hemispheres	887.7
2166	Male, age 80, both hemispheres	868.9

Nucleus raphe magnus
nTPM: 836.3

2160	Male, age 61, both hemispheres	975.4
2455	Male, age 74, both hemispheres	936.7
2051	Male, age 76, both hemispheres	899.7
2328	Male, age 80, both hemispheres	818.9
2459	Female, age 91, both hemispheres	781.7
2172	Female, age 85, both hemispheres	605.5

Paramedian reticular nucleus
nTPM: 934.1

2057	Male, age 80, both hemispheres	1073.7
2313	Male, age 61, both hemispheres	1041.5
2050	Female, age 85, both hemispheres	857.1
2052	Male, age 76, both hemispheres	764.0

Pedunculopontine tegmental nucleus
nTPM: 1079.4

2334	Male, age 80, both hemispheres	1148.9
1921	Female, age 85, both hemispheres	1130.8
2338	Male, age 61, both hemispheres	958.5

Pontine nuclei
nTPM: 958.9

1863	Male, age 55, unknown	1194.2
1968	Male, age 76, left hemisphere	1095.1
2787	Female, age 85, both hemispheres	1004.1
2319	Female, age 91, both hemispheres	943.8
2115	Male, age 80, left hemisphere	904.6
2454	Male, age 74, left hemisphere	864.3
2727	Male, age 61, right hemisphere	859.8
2109	Female, age 72, unknown	805.1

Pontine raphe nucleus
nTPM: 1079.8

2853	Male, age 76, midline	1126.6
2122	Female, age 85, midline	1033.0

Posteroventral cochlear nucleus
nTPM: 1115.2

2371	Male, age 61, both hemispheres	1370.1
2752	Female, age 85, both hemispheres	1093.4
2135	Female, age 91, both hemispheres	1082.1
2070	Male, age 76, both hemispheres	1016.5
2341	Male, age 80, both hemispheres	1014.1

Principal sensory trigeminal nucleus
nTPM: 945.8

2324	Male, age 76, both hemispheres	1121.1
2158	Male, age 61, both hemispheres	917.0
2008	Male, age 80, left hemisphere	887.9
2367	Female, age 91, left hemisphere	857.4

Reticular pontine nucleus, caudal
nTPM: 963.3

2092	Male, age 76, both hemispheres	1211.4
2457	Female, age 91, both hemispheres	935.2
2559	Male, age 74, both hemispheres	904.0
2332	Male, age 80, right hemisphere	802.6

Reticular pontine nucleus, oral
nTPM: 1057.7

1939	Male, age 80, both hemispheres	1381.3
2167	Male, age 76, both hemispheres	1163.1
2012	Female, age 85, both hemispheres	1013.5
2366	Female, age 91, both hemispheres	928.1
2361	Male, age 74, both hemispheres	802.4

Reticulotegmental nucleus
nTPM: 1058.4

2333	Male, age 80, both hemispheres	1147.7
2325	Male, age 76, both hemispheres	1122.8
2322	Female, age 91, both hemispheres	1016.7
2452	Male, age 74, both hemispheres	946.5

Spinal trigeminal nucleus, oral
nTPM: 1003.0

1978	Male, age 76, both hemispheres	1056.6
2737	Female, age 85, both hemispheres	1049.0
2164	Male, age 80, both hemispheres	903.5

Subcoeruleus area
nTPM: 1067.6

2369	Female, age 85, left hemisphere	1246.4
2451	Male, age 74, both hemispheres	1140.1
1958	Male, age 80, both hemispheres	1075.5
2089	Male, age 76, left hemisphere	988.3
2323	Female, age 91, left hemisphere	887.6

Superior olive
nTPM: 880.7

2020	Male, age 76, both hemispheres	1119.9
2364	Male, age 74, right hemisphere	936.8
1875	Female, age 85, both hemispheres	824.0
2329	Male, age 80, right hemisphere	776.1
2561	Female, age 91, both hemispheres	746.7

Ventral periolivary nuclei
nTPM: 854.5

2023	Male, age 76, both hemispheres	1034.2
2165	Male, age 80, both hemispheres	989.9
2794	Female, age 91, left hemisphere	708.1
2130	Female, age 85, both hemispheres	685.9

Ventrolateral tegmental area, A5 NE cell group
nTPM: 895.5

2359	Male, age 61, both hemispheres	1195.3
1959	Male, age 76, both hemispheres	953.7
2456	Female, age 91, both hemispheres	876.9
2161	Male, age 80, both hemispheres	848.1
2449	Male, age 74, both hemispheres	770.5
2840	Female, age 85, both hemispheres	728.3

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	620.6

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 620.6

FF:10165-103B3	76 years, female	642.3
FF:10182-103D2	60 years, female	598.8

Pons
Scaled Tags Per Million: 350.2

FF:10033-101E6

18-54 years, mixed

350.2

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	1520.5

Pig sample

Sample description

nTPM

Pons
nTPM: 1520.5

Samples: 3

Max nTPM: 1835.9
Min nTPM: 1001.7

Sample A	Female	1723.8
Sample B	Female	1001.7
Sample C	Male	1835.9

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	760.9

Rat sample

Sample description

nTPM

Pons
nTPM: 760.9

Samples: 4

Max nTPM: 780.6
Min nTPM: 717.8

Sample A		780.6
Sample A		772.6
Sample A		717.8
Sample A		772.7