Brain tissue expression of RPS10 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	364.4	nTPM
FANTOM5:	231.2	Scaled Tags Per Million

Mouse:	294.8	nTPM
Rat:	50.0	nTPM
Pig:	495.0	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	364.4

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 333.8

2090	Male, age 80, both hemispheres	376.0
2188	Female, age 91, both hemispheres	373.5
2301	Female, age 85, both hemispheres	300.8
1984	Male, age 76, both hemispheres	284.9

Dorsal cochlear nucleus
nTPM: 351.4

2802	Male, age 74, right hemisphere	422.2
2187	Female, age 91, both hemispheres	345.9
2378	Male, age 80, both hemispheres	340.7
2370	Male, age 61, both hemispheres	330.5
2058	Male, age 76, both hemispheres	317.7

Dorsal tegmental nucleus
nTPM: 364.2

2083	Male, age 80, both hemispheres	404.7
2326	Male, age 74, both hemispheres	399.6
2358	Male, age 61, both hemispheres	357.2
1936	Male, age 76, left hemisphere	295.2

Dorsolateral tegmental area
nTPM: 350.0

2654	Male, age 80, both hemispheres	404.9
2337	Male, age 61, both hemispheres	394.5
2751	Female, age 85, both hemispheres	360.1
2360	Male, age 74, both hemispheres	314.0
2141	Male, age 76, both hemispheres	276.4

Kolliker-Fuse nucleus
nTPM: 335.3

2315	Male, age 76, right hemisphere	404.9
2793	Female, age 91, left hemisphere	302.1
2163	Male, age 80, both hemispheres	298.9

Lateral lemniscal nuclei
nTPM: 260.8

2169	Male, age 76, both hemispheres	296.7
2746	Female, age 85, left hemisphere	278.3
2453	Male, age 74, right hemisphere	260.2
2320	Female, age 91, left hemisphere	257.7
2036	Male, age 80, both hemispheres	211.3

Lateral parabrachial nucleus
nTPM: 342.7

2013	Male, age 80, both hemispheres	370.0
2790	Male, age 61, both hemispheres	335.6
2792	Male, age 76, both hemispheres	333.6
2139	Female, age 85, right hemisphere	331.8

Lateral vestibular nucleus
nTPM: 305.8

2311	Male, age 80, both hemispheres	357.1
2184	Male, age 76, both hemispheres	254.4

Locus coeruleus
nTPM: 303.2

2123	Female, age 91, both hemispheres	349.6
2720	Male, age 74, both hemispheres	326.3
2317	Female, age 72, unknown	316.0
2162	Male, age 80, both hemispheres	306.3
2014	Male, age 55, unknown	281.9
2788	Male, age 74, unknown	276.1
1980	Male, age 76, both hemispheres	266.5

Medial parabrachial nucleus
nTPM: 328.1

2170	Female, age 91, both hemispheres	389.1
2156	Male, age 61, both hemispheres	335.4
2463	Female, age 85, right hemisphere	325.1
2854	Male, age 80, both hemispheres	297.2
2786	Male, age 76, both hemispheres	293.6

Medial periolivary nuclei
nTPM: 287.8

2063	Male, age 76, both hemispheres	371.1
2081	Male, age 80, both hemispheres	297.4
2458	Female, age 91, both hemispheres	268.3
2791	Male, age 74, right hemisphere	251.9
2171	Female, age 85, both hemispheres	250.6

Motor facial nucleus
nTPM: 282.2

2062	Male, age 76, both hemispheres	339.6
2795	Female, age 91, both hemispheres	313.1
2126	Male, age 61, both hemispheres	288.4
2365	Male, age 74, right hemisphere	276.5
2697	Female, age 85, both hemispheres	265.9
2327	Male, age 80, both hemispheres	209.4

Motor trigeminal nucleus
nTPM: 296.4

2335	Male, age 61, both hemispheres	322.2
2309	Male, age 76, both hemispheres	319.9
2560	Male, age 74, both hemispheres	303.0
2321	Female, age 91, both hemispheres	272.7
2079	Male, age 80, both hemispheres	264.4

Nuclei of the trapezoid body
nTPM: 286.8

1983	Male, age 76, both hemispheres	397.3
2735	Female, age 85, both hemispheres	269.9
2166	Male, age 80, both hemispheres	264.0
2368	Female, age 91, both hemispheres	262.5
2159	Male, age 61, both hemispheres	240.3

Nucleus raphe magnus
nTPM: 264.9

2051	Male, age 76, both hemispheres	283.7
2459	Female, age 91, both hemispheres	279.1
2455	Male, age 74, both hemispheres	265.4
2160	Male, age 61, both hemispheres	260.4
2328	Male, age 80, both hemispheres	254.1
2172	Female, age 85, both hemispheres	246.8

Paramedian reticular nucleus
nTPM: 293.8

2057	Male, age 80, both hemispheres	315.0
2313	Male, age 61, both hemispheres	309.0
2052	Male, age 76, both hemispheres	285.7
2050	Female, age 85, both hemispheres	265.6

Pedunculopontine tegmental nucleus
nTPM: 323.9

2338	Male, age 61, both hemispheres	362.0
2334	Male, age 80, both hemispheres	349.4
1921	Female, age 85, both hemispheres	260.3

Pontine nuclei
nTPM: 308.8

2787	Female, age 85, both hemispheres	344.0
1863	Male, age 55, unknown	342.5
2319	Female, age 91, both hemispheres	334.9
1968	Male, age 76, left hemisphere	331.4
2109	Female, age 72, unknown	305.4
2115	Male, age 80, left hemisphere	286.1
2454	Male, age 74, left hemisphere	270.7
2727	Male, age 61, right hemisphere	255.4

Pontine raphe nucleus
nTPM: 304.9

2122	Female, age 85, midline	316.0
2853	Male, age 76, midline	293.8

Posteroventral cochlear nucleus
nTPM: 364.4

2341	Male, age 80, both hemispheres	416.1
2371	Male, age 61, both hemispheres	393.5
2135	Female, age 91, both hemispheres	382.7
2070	Male, age 76, both hemispheres	317.0
2752	Female, age 85, both hemispheres	312.6

Principal sensory trigeminal nucleus
nTPM: 253.1

2158	Male, age 61, both hemispheres	271.7
2367	Female, age 91, left hemisphere	257.5
2324	Male, age 76, both hemispheres	254.1
2008	Male, age 80, left hemisphere	229.0

Reticular pontine nucleus, caudal
nTPM: 308.1

2092	Male, age 76, both hemispheres	367.4
2559	Male, age 74, both hemispheres	341.3
2457	Female, age 91, both hemispheres	306.4
2332	Male, age 80, right hemisphere	217.1

Reticular pontine nucleus, oral
nTPM: 302.5

2167	Male, age 76, both hemispheres	331.5
2366	Female, age 91, both hemispheres	324.8
1939	Male, age 80, both hemispheres	318.0
2012	Female, age 85, both hemispheres	279.3
2361	Male, age 74, both hemispheres	258.8

Reticulotegmental nucleus
nTPM: 306.0

2452	Male, age 74, both hemispheres	393.6
2333	Male, age 80, both hemispheres	287.1
2322	Female, age 91, both hemispheres	273.2
2325	Male, age 76, both hemispheres	270.2

Spinal trigeminal nucleus, oral
nTPM: 282.2

1978	Male, age 76, both hemispheres	292.3
2164	Male, age 80, both hemispheres	287.4
2737	Female, age 85, both hemispheres	266.9

Subcoeruleus area
nTPM: 327.4

2451	Male, age 74, both hemispheres	452.7
2369	Female, age 85, left hemisphere	354.4
2323	Female, age 91, left hemisphere	292.0
1958	Male, age 80, both hemispheres	286.1
2089	Male, age 76, left hemisphere	251.6

Superior olive
nTPM: 262.3

2020	Male, age 76, both hemispheres	331.1
2561	Female, age 91, both hemispheres	268.2
1875	Female, age 85, both hemispheres	246.3
2364	Male, age 74, right hemisphere	241.9
2329	Male, age 80, right hemisphere	224.1

Ventral periolivary nuclei
nTPM: 285.0

2023	Male, age 76, both hemispheres	339.0
2165	Male, age 80, both hemispheres	279.5
2794	Female, age 91, left hemisphere	267.8
2130	Female, age 85, both hemispheres	253.9

Ventrolateral tegmental area, A5 NE cell group
nTPM: 293.5

2359	Male, age 61, both hemispheres	327.0
2161	Male, age 80, both hemispheres	313.1
2456	Female, age 91, both hemispheres	303.3
1959	Male, age 76, both hemispheres	287.3
2449	Male, age 74, both hemispheres	274.7
2840	Female, age 85, both hemispheres	255.5

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	231.2

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 231.2

FF:10165-103B3	76 years, female	245.5
FF:10182-103D2	60 years, female	216.9

Pons
Scaled Tags Per Million: 185.7

FF:10033-101E6

18-54 years, mixed

185.7

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	495.0

Pig sample

Sample description

nTPM

Pons
nTPM: 495.0

Samples: 3

Max nTPM: 647.6
Min nTPM: 356.1

Sample A	Female	481.3
Sample B	Female	356.1
Sample C	Male	647.6

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	294.8

Mouse sample

Sample description

nTPM

Pons
nTPM: 294.8

Samples: 4

Max nTPM: 306.7
Min nTPM: 288.9

Sample A		288.9
Sample B		290.3
Sample C		306.7
Sample D		293.4

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	50.0

Rat sample

Sample description

nTPM

Pons
nTPM: 50.0

Samples: 4

Max nTPM: 55.9
Min nTPM: 46.2

Sample A		55.9
Sample A		48.5
Sample A		49.4
Sample A		46.2