CELSR1

GENERAL INFORMATION

? »

Gene name

CELSR1

Gene description

Cadherin, EGF LAG seven-pass G-type receptor 1

Protein class

Disease related genes
G-protein coupled receptors
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending external verification. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 1 antibody.
HPA067269
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

? »

Gene name

CELSR1 (HGNC Symbol)

Synonyms

CDHF9, FMI2, HFMI2, ME2

Description

Cadherin, EGF LAG seven-pass G-type receptor 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q13.31

Chromosome location (bp)

46360834 - 46537170

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000075275 (version 78.38)

Entrez gene

9620

UniProt

Q9NYQ6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NYQ6

Antibodypedia

CELSR1 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000262738
 
ENST00000454637
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CELSR1-001 ENSP00000262738
ENST00000262738
Q9NYQ6
Show all »
Show » Show » 3014 329.5 Yes 7
CELSR1-002 ENSP00000414689
ENST00000454637
Show » Show » 772 85.4 No 0