GRHL2

GENERAL INFORMATION

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Gene name

GRHL2

Gene description

Grainyhead-like 2 (Drosophila)

Protein class

Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Moderate or strong nuclear staining was observed in urothelium, trophoblasts, prostate, squamous and airway epithelia. The gastrointestinal tract, gall bladder, neurons, islets of Langerhans, heart and skeletal muscle cytoplasmic staining. Remaining tissues were in general weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA004820
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

GRHL2 (HGNC Symbol)

Synonyms

BOM, DFNA28, FLJ13782, TFCP2L3

Description

Grainyhead-like 2 (Drosophila) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).[provided by RefSeq, Mar 2009]

Chromosome

8

Cytoband

q22.3

Chromosome location (bp)

101492432 - 101669726

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000083307 (version 78.38)

Entrez gene

79977

UniProt

Q6ISB3 (UniProt - Evidence at protein level)

neXtProt

NX_Q6ISB3

Antibodypedia

GRHL2 antibodies


PROTEIN BROWSER

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ENST00000251808
 
ENST00000395927
 
ENST00000521085
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GRHL2-001 ENSP00000251808
ENST00000251808
Q6ISB3
Show all »
Show » Show » 625 71.1 No 0
GRHL2-002 ENSP00000379260
ENST00000395927
Q6ISB3
Show all »
Show » Show » 609 69.3 No 0
GRHL2-005 ENSP00000430473
ENST00000521085
Show » 6 0.7 No 0