KCND1

GENERAL INFORMATION

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Gene name

KCND1

Gene description

Potassium voltage-gated channel, Shal-related subfamily, member 1

Protein class

FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

Intracellular,Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Bile duct cells, islet cells in pancreas, testis and renal tubuli showed moderate cytoplasmic expression with additional membranous positivity. Remaining normal cells were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA001066
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

KCND1 (HGNC Symbol)

Synonyms

Kv4.1

Description

Potassium voltage-gated channel, Shal-related subfamily, member 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013]

Chromosome

X

Cytoband

p11.23

Chromosome location (bp)

48961378 - 48971569

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000102057 (version 78.38)

Entrez gene

3750

UniProt

Q9NSA2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NSA2

Antibodypedia

KCND1 antibodies


PROTEIN BROWSER

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ENST00000218176
 
ENST00000376477
 
ENST00000419374
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCND1-001 ENSP00000218176
ENST00000218176
Q9NSA2
Show all »
Show » Show » 647 71.3 Yes 6
KCND1-002 ENSP00000365660
ENST00000376477
A6NEF1
Show all »
Show » Show » 270 28.9 No 1
KCND1-003 ENSP00000413989
ENST00000419374
Show » 133 14.1 No 0