DGUOK

GENERAL INFORMATION

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Gene name

DGUOK

Gene description

Deoxyguanosine kinase

Protein class

Disease related genes
Enzymes
Mitochondrial proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most tissues at variable levels.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 2 antibodies.
HPA034766 , HPA057246
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

DGUOK (HGNC Symbol)

Synonyms

dGK

Description

Deoxyguanosine kinase (HGNC Symbol)

Entrez gene summary

In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p13.1

Chromosome location (bp)

73926826 - 73958961

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114956 (version 78.38)

Entrez gene

1716

UniProt

Q16854 (UniProt - Evidence at protein level)

neXtProt

NX_Q16854

Antibodypedia

DGUOK antibodies


PROTEIN BROWSER

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ENST00000264093
 
ENST00000348222
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DGUOK-001 ENSP00000264093
ENST00000264093
Q16854
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Show » Show » 277 32.1 No 0
DGUOK-002 ENSP00000306964
ENST00000348222
Q16854
Show all »
Show » Show » 189 21.4 No 0