KCNK17

GENERAL INFORMATION

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Gene name

KCNK17

Gene description

Potassium channel, subfamily K, member 17

Protein class

Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Tissue enhanced (lung, thyroid gland)

Protein evidence

Evidence at transcript level

Protein localization

Most normal tissues cells were negative. Cells in seminiferus ducts showed strong nuclear positivity. Glandular cells of gastrointestinal tract displayed moderate cytoplasmic and membranous staining.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA043892
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (lung, thyroid gland)

Organ

Expression



GENE INFORMATION

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Gene name

KCNK17 (HGNC Symbol)

Synonyms

K2p17.1, TALK-2, TALK2, TASK-4, TASK4

Description

Potassium channel, subfamily K, member 17 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Chromosome

6

Cytoband

p21.2

Chromosome location (bp)

39299001 - 39314553

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000124780 (version 78.38)

Entrez gene

89822

UniProt

Q96T54 (UniProt - Evidence at transcript level)

neXtProt

NX_Q96T54

Antibodypedia

KCNK17 antibodies


PROTEIN BROWSER

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ENST00000373231
 
ENST00000453413
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNK17-001 ENSP00000362328
ENST00000373231
Q96T54
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Show » Show » 332 36.9 No 6
KCNK17-002 ENSP00000401271
ENST00000453413
Q96T54
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Show » Show » 271 30 No 5