THE HUMAN PROTEIN ATLAS BLOG

Important link between genomics and proteomics

2016-10-25
Genomics Mass Spectrometry Proteomics

Several previous reports have concluded that RNA levels cannot be used to predict protein levels. However, in a new study from KTH Royal Institute of Technology, published in the journal Molecular Systems Biology scientists from the Human Protein Atlas show that protein levels can be predicted from RNA levels if a gene-specific RNA-to-protein factor is used.

The human genome consists of DNA, a molecule that contains the instructions needed to build and maintain cells. For the instructions to be carried out, DNA must be read and transcribed into RNA transcripts that can be used to produce protein. The transcriptome is a collection of all the transcripts present in a cell...Read more


A systems approach to the liver

2016-07-26
Genomics Liver Metabolomics Phenomics Proteomics Transcriptomics

Multiscale -omics technologies and integrated network approaches unveiled the link between genetic variance and phenotypic differences in liver.

In a recent number of Nature Reviews, Human Protein Atlas researchers Mathias UhlÚn and Adil Mardinoglu discuss a study by E.G. Williams and co workers in Science where five complementary -omics datasets across various environmental states (including genomics, transcriptomics, proteomics, metabolomics and phenomics) using the liver as a platform for multiomics analysis are integrated...Read more