News Articles


New treatment attacking liver disease and diabetes

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Researchers from the Human Protein Atlas are planning a clinical trial of a new treatment for nonalcoholic fatty liver disease and type 2 diabetes which harnesses liver cells own ability to burn accumulated fats...Read more


Computational scientist with a focus on the liver

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Adil Mardinoglu is a SciLifeLab fellow and the newest addition to the Protein Atlas team of principal investigators. He is the leader of the systems biology group, a group that create biological networks to identify drug targets and discover biomarkers for the development of efficient treatment strategies.

But Adil´s background is not in medicine, he is an electronic engineer with a PhD in computational biology.

– I did my PhD in Ireland where I worked with magnetic drug targeting, he says.

After a one year post doc doing research on neuronal networks, Adil Mardinoglu moved to Chalmers in Gothenburg to join Jens Nielsens group in systems biology...Read more


Integrated networks for obese subjects

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In a paper in a recent issue of Cell Metabolism, Human Protein Atlas-researchers investigate the biological processes that are altered in obese subjects.

Obesity is associated with an increased risk for a wide range of morbidities, including insulin resistance, type 2 diabetes, non-alcoholic fatty liver disease, and cardiovascular disease. Although the prevalence of obesity continues to dramatically increase worldwide, a clear understanding of the underlying molecular mechanisms involved in the progression of associated disorders is still lacking...Read more


A systems approach to the liver

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In a recent number of Nature Reviews, Human Protein Atlas researchers Mathias Uhlén and Adil Mardinoglu discuss a study by E.G. Williams and co workers in Science where five complementary -omics datasets across various environmental states (including genomics, transcriptomics, proteomics, metabolomics and phenomics) using the liver as a platform for multiomics analysis are integrated...Read more


Proteins in drug-induced liver injuries

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Last week, researchers from the Human Protein Atlas, together with others, published a study on drug-induced liver injury in the journal Liver International.

Drug-induced liver injury is the single leading cause for termination of drug development and safety-related withdrawal of approved drugs from the market. In clinical practice, it accounts for more than 50% of liver failure cases and represents a major safety issue for patients. In some patients, drug-induced liver injury can cause severe injury leading to acute liver failure that can be life threatening and require liver transplantation...Read more


Upcoming Events


Single Cells: Technology to Biology

February 24, 2019 - February 26, 2019

Dr. Emma Lundberg, will give a presentation on "Dissecting spatiotemporal variations of the human proteome" at the Cell Symposium "Single Cells: Technology to Biology" held at the A* STAR Genome Institute of Singapore. She will present on Monday February 25, at 16:15.
Programme

9th Alpbach Workshop on Affinity Proteomics

March 11, 2019 - March 13, 2019

The 9th Alpbach workshop will take place in the state-of-the-art Congress Centre in Alpbach/Austria.