THE HUMAN PROTEIN ATLAS BLOG

Elevated expression of CD93 in brain tumor

2015-11-03
Brain cancer Cancer CD93 Glioblastoma Tissue Atlas

CD93 expression in pathological blood vessels in a case of high-grade malignant glioma

Elevated expression of the C-type lectin CD93 in the glioblastoma vasculature regulates cytoskeletal rearrangements that enhance vessel function and reduce host survival

CD93 encodes for a cell-surface glycoprotein and is expressed in myeloid cells and endothelial cells. CD93 has recently been identified as an important gene in primary tumor angiogenesis and the corresponding protein has been shown to have proangiogenic properties. In the present study the role of CD93 in malignant glioma was analyzed. The effect on glioblastoma vessels and tumor growth was studied...Read more