Gliomas are a group of brain tumors that originate from different types of glial cells in the central nervous system. The prognosis for glioma is generally poor due to limited possibilities for curative treatment. By using a systems level approach to analyze the glioma proteome with respect to clinical outcome based on genome-wide transcriptomics, 263 genes were found to be associated with prognostic outcome...Read more
The last decades of technical development and availability of protein and peptide microarrays have enabled large-scale profiling of antibodies and precise determination of their specificities through epitope mapping. This has enabled characterization of the human immune response and the produced antibodies within a wide range of disorder. This approach not only explores the auto-antibody repertoire but also identifies key antigens that targeted by the antibodies in e.g. neurodegenerative disorders.
Arash Zandian defended his PhD-thesis "Array-based autoantibody profiling and epitope mapping" on October 6th where he presented the work he has performed during the last 4 years at SciLifeLab, School of Biotechnology, KTH Royal Institute of Technology.
In this thesis the aim was to use affinity proteomics tools to profile antibodies, determine their specificities, and discover potential associations of autoantigens to disease by analyzing blood-derived samples with microarray-based methods. Here described with articles in the field of narcolepsy, multiple sclerosis, psychosis and malaria...Read more
1527 genes are found to be associated with prognosis in pancreatic cancers and 670 of them correlate with unfavourable prognosis. As part of the Pathology Atlas, release, we present brief and informative summaries of all cancers, and highlight genes with prognostic association in the different cancer forms...Read more
Mitochondrial pyruvate carrier and calcium binding protein S100A16 are two genes whose expression is associated with favorable and unfavorable prognosis in lung cancer, one of the deadliest cancer forms...Read more
In this week's Pathology Atlas blog post, we highlight genes with prognostic association to ovarian cancer , as September is National Ovarian Cancer Awareness Month in the US. Ovarian cancer is the fifth most frequent cause of cancer death in women, and 50% of all ovarian cancers are diagnosed in women older than 65 years of age.
Epithelial ovarian carcinoma is one of the most common gynecologic malignancy. There are five subtypes of epithelial ovarian carcinoma, of which high-grade serous carcinoma is the most common...Read more
February 28, 2018 - March 2, 2018
The Wellcome Genome Campus organizes the conference Proteomics in Cell Biology and Disease Mechanisms where Dr. Emma Lundberg will present "Dissecting the spatiotemporal subcellular distribution of the human proteome". Her talk is scheduled on March 2. Draft programme