Pyruvate kinase muscle type (PKM) is a key enzyme in glycolysis and is a mediator of the Warburg effect in tumors. The association of PKM with survival of cancer patients is controversial. This study investigated the associations of the alternatively spliced transcripts of PKM with cancer patients' survival outcomes and explained the conflicts in previous studies. The article has recently been published in the journal Cancers...Read more

Over time, cells accumulate DNA mutations, that if transcribed and translated influence gene expression and/or function of the protein. The increasing number mutations in eg. genes that control cell division eventually lead formation of tumor...Read more

Cancer rates are steadily increasing worldwide and are projected to continue to rise during the next decade. But what part of it is a true increase and what part is influenced by other factors, such as reporting and quality of various cancer registries, is unclear. In this week's blog post, we will highlight some of the common terms used when discussing cancer statistics and what to consider when interpreting it...Read more

A bit more than two decades ago, the first Diablo game was released to the world. A game about a lone hero tasked with bringing down Diablo, one of the lords of Hell. This month we highlight a namesake to this hellish lord of terror, the protein DIABLO...Read more

Testicular cancer is a rare type of cancer. Most testis cancers are curable, even at an advanced stage. The cancer can be divided into essentially two categories: Seminoma and Non-seminomatous germ cell tumors. Based on transcriptomics data and clinical metadata we have been able to determine 57 genes associated with either favorable or unfavorable prognosis in testis cancer...Read more