THE HUMAN PROTEIN ATLAS BLOG

New treatment attacking liver disease and diabetes

2017-03-14
Liver Metabolic networks

Researchers from the Human Protein Atlas are planning a clinical trial of a new treatment for nonalcoholic fatty liver disease and type 2 diabetes which harnesses liver cells own ability to burn accumulated fats.

In a study involving 86 patients with varying degrees of fatty liver disease, researchers found that the liver has the ability to burn up accumulated fats. The researchers propose a mixture of substances that will set this process in motion.

Assistant Professor Adil Mardinoglu says the teamīs metabolic modeling approach, which relied on data from the Human Protein Atlas project, can be used for a number of chronic liver diseases...Read more


Network-based approach to study lipid metabolism

2016-08-23
Lipid enzymes Liver cancer Metabolic networks Systems biology

Sunjae Lee

In a recent publication in Nucleic Acids Research, researchers from the Systems Biology group at the Human Protein Atlas investigated anomalies in regulation of lipid metabolism in the liver, in association with hepatocellular carcinoma.

Hepatocellular carcinoma has a high mortality rate and early detection of the disease is crucial for the application of effective treatment strategies. Several lines of evidence imply that lipid anomalies underlie the hepatocellular carcinoma pathogenesis.

Here, the researchers applied a tailored network-based approach to identify signaling hubs associated with regulation of this part of the metabolism...Read more