Previous news articles featured the history and technology behind two powerful tools for visualizing proteins in tissues: immunohistochemistry and microscopy. These tools are applied to investigate and answer a wide range of questions, both in healthcare and research. This article focuses on two applications related to lung cancer: diagnostics in clinical pathology and discovery of genes associated with prognosis...Read more
Today, it is time for the first image of the week from the Cancer Atlas!
Lung cancer is one of the deadliest and most common forms of human cancer. Different forms of lung cancer exist and non-small cell lung cancer is the most common form. The cancer image this week is selected from such a lung cancer that has been immunohistochemically stained for the proliferation marker Ki-67 (MKI67). Ki-67 is the most commonly used immunohistochemical marker in rutin cancer diagnostics. The Ki-67 antigen is expressed in all cell nuclei that are active in the cell cycle and thus positive staining in a tumor cell population reflects the level of proliferation in that particular cancer...Read more
In a study performed by scientists at Uppsala University, in collaboration with Gothenburg University and the Human Protein Atlas project, the expression of cyclooxygenase-2 (COX-2) was evaluated in patients with non-small cell lung cancer (NSCLC).
To clarify previous inconsistences concerning the prognostic impact of COX-2 expression in NSCLC, the association between COX-2 transcript levels (encoded by the gene PTGS2) and overall survival in nine publicly available gene expression microarray data sets were evaluated as well as the in situ protein expression of COX-2 in tumor and stromal cells in two independent NSCLC cohorts...Read more
November 14, 2018 - November 14, 2018
Dr Charlotte Stadler is Plenary Keynote Speaker presenting "An image based subcellular map of the human proteome" at the The 6th biennial Pharmaceutical Flow Cytometry and Imaging meeting, Stevenage, UK.Overview
December 8, 2018 - December 12, 2018
The Human Protein Atlas will be exhibiting at the 2018 ASCB EMBO meeting in San Diego. In booth number #624 you will meet the Cell Atlas team Emma Lundberg, Christian Gnann, Lovisa Åkesson and Peter Thul. They will also present four posters. Preliminary programme