Brain tissue expression of ACTB in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	2395.0	nTPM
FANTOM5:	2932.9	Scaled Tags Per Million

Macaque:	1209.5	nTPM
Mouse:	928.0	nTPM
Pig:	2269.9	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	2395.0

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 2054.8

2301	Female, age 85, both hemispheres	2493.8
2090	Male, age 80, both hemispheres	2304.3
2188	Female, age 91, both hemispheres	1972.1
1984	Male, age 76, both hemispheres	1449.0

Dorsal cochlear nucleus
nTPM: 1972.2

2187	Female, age 91, both hemispheres	2313.9
2370	Male, age 61, both hemispheres	2136.0
2378	Male, age 80, both hemispheres	1835.2
2802	Male, age 74, right hemisphere	1795.9
2058	Male, age 76, both hemispheres	1780.2

Dorsal tegmental nucleus
nTPM: 2395.0

2358	Male, age 61, both hemispheres	3807.3
2326	Male, age 74, both hemispheres	2207.6
2083	Male, age 80, both hemispheres	1961.9
1936	Male, age 76, left hemisphere	1603.1

Dorsolateral tegmental area
nTPM: 2091.5

2337	Male, age 61, both hemispheres	3420.8
2654	Male, age 80, both hemispheres	1953.6
2360	Male, age 74, both hemispheres	1878.3
2751	Female, age 85, both hemispheres	1830.7
2141	Male, age 76, both hemispheres	1373.8

Kolliker-Fuse nucleus
nTPM: 2182.6

2163	Male, age 80, both hemispheres	2218.5
2793	Female, age 91, left hemisphere	2174.7
2315	Male, age 76, right hemisphere	2154.6

Lateral lemniscal nuclei
nTPM: 1776.4

2746	Female, age 85, left hemisphere	1927.3
2453	Male, age 74, right hemisphere	1813.3
2169	Male, age 76, both hemispheres	1778.7
2320	Female, age 91, left hemisphere	1711.7
2036	Male, age 80, both hemispheres	1651.3

Lateral parabrachial nucleus
nTPM: 1997.7

2792	Male, age 76, both hemispheres	2239.8
2013	Male, age 80, both hemispheres	2044.2
2790	Male, age 61, both hemispheres	1976.0
2139	Female, age 85, right hemisphere	1730.7

Lateral vestibular nucleus
nTPM: 2125.2

2311	Male, age 80, both hemispheres	2289.9
2184	Male, age 76, both hemispheres	1960.6

Locus coeruleus
nTPM: 1701.2

2123	Female, age 91, both hemispheres	1950.9
2720	Male, age 74, both hemispheres	1839.5
2162	Male, age 80, both hemispheres	1772.9
1980	Male, age 76, both hemispheres	1715.9
2014	Male, age 55, unknown	1675.8
2317	Female, age 72, unknown	1653.5
2788	Male, age 74, unknown	1300.0

Medial parabrachial nucleus
nTPM: 2045.5

2170	Female, age 91, both hemispheres	2635.4
2854	Male, age 80, both hemispheres	2132.4
2156	Male, age 61, both hemispheres	2006.4
2786	Male, age 76, both hemispheres	1812.3
2463	Female, age 85, right hemisphere	1640.8

Medial periolivary nuclei
nTPM: 1888.5

2081	Male, age 80, both hemispheres	2158.5
2791	Male, age 74, right hemisphere	2152.6
2063	Male, age 76, both hemispheres	1766.1
2458	Female, age 91, both hemispheres	1732.8
2171	Female, age 85, both hemispheres	1632.8

Motor facial nucleus
nTPM: 1805.6

2365	Male, age 74, right hemisphere	2485.1
2126	Male, age 61, both hemispheres	1919.3
2697	Female, age 85, both hemispheres	1900.7
2062	Male, age 76, both hemispheres	1743.3
2795	Female, age 91, both hemispheres	1486.1
2327	Male, age 80, both hemispheres	1299.2

Motor trigeminal nucleus
nTPM: 1924.1

2335	Male, age 61, both hemispheres	2471.7
2560	Male, age 74, both hemispheres	2009.4
2321	Female, age 91, both hemispheres	1835.6
2309	Male, age 76, both hemispheres	1703.5
2079	Male, age 80, both hemispheres	1600.4

Nuclei of the trapezoid body
nTPM: 1609.8

1983	Male, age 76, both hemispheres	1820.5
2159	Male, age 61, both hemispheres	1637.9
2166	Male, age 80, both hemispheres	1592.5
2735	Female, age 85, both hemispheres	1580.9
2368	Female, age 91, both hemispheres	1417.2

Nucleus raphe magnus
nTPM: 1718.1

2455	Male, age 74, both hemispheres	2108.9
2051	Male, age 76, both hemispheres	1986.4
2160	Male, age 61, both hemispheres	1619.3
2328	Male, age 80, both hemispheres	1535.6
2459	Female, age 91, both hemispheres	1534.2
2172	Female, age 85, both hemispheres	1523.9

Paramedian reticular nucleus
nTPM: 1824.4

2313	Male, age 61, both hemispheres	1926.3
2057	Male, age 80, both hemispheres	1889.9
2052	Male, age 76, both hemispheres	1806.9
2050	Female, age 85, both hemispheres	1674.4

Pedunculopontine tegmental nucleus
nTPM: 2215.0

2338	Male, age 61, both hemispheres	3178.8
2334	Male, age 80, both hemispheres	2112.1
1921	Female, age 85, both hemispheres	1354.2

Pontine nuclei
nTPM: 2034.9

2109	Female, age 72, unknown	2250.6
2454	Male, age 74, left hemisphere	2239.7
2115	Male, age 80, left hemisphere	2227.3
2319	Female, age 91, both hemispheres	2134.5
1863	Male, age 55, unknown	2121.1
2787	Female, age 85, both hemispheres	1881.6
1968	Male, age 76, left hemisphere	1847.6
2727	Male, age 61, right hemisphere	1577.1

Pontine raphe nucleus
nTPM: 1515.5

2853	Male, age 76, midline	1537.5
2122	Female, age 85, midline	1493.5

Posteroventral cochlear nucleus
nTPM: 2107.1

2341	Male, age 80, both hemispheres	2377.8
2371	Male, age 61, both hemispheres	2296.9
2135	Female, age 91, both hemispheres	2215.2
2070	Male, age 76, both hemispheres	2014.6
2752	Female, age 85, both hemispheres	1630.8

Principal sensory trigeminal nucleus
nTPM: 1736.3

2324	Male, age 76, both hemispheres	2025.0
2367	Female, age 91, left hemisphere	2003.9
2158	Male, age 61, both hemispheres	1493.9
2008	Male, age 80, left hemisphere	1422.5

Reticular pontine nucleus, caudal
nTPM: 1736.3

2559	Male, age 74, both hemispheres	2215.8
2092	Male, age 76, both hemispheres	1867.3
2457	Female, age 91, both hemispheres	1610.7
2332	Male, age 80, right hemisphere	1251.3

Reticular pontine nucleus, oral
nTPM: 1859.2

2361	Male, age 74, both hemispheres	2337.2
1939	Male, age 80, both hemispheres	1886.4
2167	Male, age 76, both hemispheres	1789.3
2366	Female, age 91, both hemispheres	1678.0
2012	Female, age 85, both hemispheres	1605.1

Reticulotegmental nucleus
nTPM: 1895.1

2452	Male, age 74, both hemispheres	2102.9
2322	Female, age 91, both hemispheres	2030.6
2333	Male, age 80, both hemispheres	1851.1
2325	Male, age 76, both hemispheres	1595.9

Spinal trigeminal nucleus, oral
nTPM: 1877.8

2164	Male, age 80, both hemispheres	1990.9
2737	Female, age 85, both hemispheres	1880.1
1978	Male, age 76, both hemispheres	1762.3

Subcoeruleus area
nTPM: 1867.3

2323	Female, age 91, left hemisphere	2051.8
2451	Male, age 74, both hemispheres	2032.2
2369	Female, age 85, left hemisphere	1883.7
1958	Male, age 80, both hemispheres	1724.0
2089	Male, age 76, left hemisphere	1644.6

Superior olive
nTPM: 1813.0

2364	Male, age 74, right hemisphere	2462.9
2020	Male, age 76, both hemispheres	1832.3
2561	Female, age 91, both hemispheres	1739.6
2329	Male, age 80, right hemisphere	1531.7
1875	Female, age 85, both hemispheres	1498.5

Ventral periolivary nuclei
nTPM: 1673.1

2023	Male, age 76, both hemispheres	1804.5
2130	Female, age 85, both hemispheres	1696.9
2794	Female, age 91, left hemisphere	1652.5
2165	Male, age 80, both hemispheres	1538.7

Ventrolateral tegmental area, A5 NE cell group
nTPM: 1934.5

2359	Male, age 61, both hemispheres	2355.4
2840	Female, age 85, both hemispheres	1995.6
2449	Male, age 74, both hemispheres	1989.9
2161	Male, age 80, both hemispheres	1887.8
1959	Male, age 76, both hemispheres	1732.8
2456	Female, age 91, both hemispheres	1645.3

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	2932.9

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 2332.7

FF:10182-103D2	60 years, female	2855.8
FF:10165-103B3	76 years, female	1809.5

Pons
Scaled Tags Per Million: 2932.9

FF:10033-101E6

18-54 years, mixed

2932.9

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	1209.5

Macaque sample

Sample description

nTPM

Pons
nTPM: 1209.4

Samples: 2

Max nTPM: 1250.3
Min nTPM: 1168.6

Sample A		1250.3
Sample B		1168.6

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	2269.9

Pig sample

Sample description

nTPM

Pons
nTPM: 2269.9

Samples: 3

Max nTPM: 2601.0
Min nTPM: 1733.4

Sample A	Female	2601.0
Sample B	Female	1733.4
Sample C	Male	2475.3

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	928.0

Mouse sample

Sample description

nTPM

Pons
nTPM: 928.0

Samples: 4

Max nTPM: 1014.7
Min nTPM: 889.4

Sample A		1014.7
Sample B		912.8
Sample C		895.1
Sample D		889.4