AK2

GENERAL INFORMATION

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Gene name

AK2

Gene description

Adenylate kinase 2

Protein class

Disease related genes
Enzymes
Mitochondrial proteins
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA018479
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

AK2

Synonyms

Description

Adenylate kinase 2 (HGNC Symbol)

Entrez gene summary

Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]

Chromosome

1

Cytoband

p35.1

Chromosome location (bp)

33007984 - 33080996

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000004455 (version 78.38)

Entrez gene

204

UniProt

P54819 (UniProt - Evidence at protein level)

neXtProt

NX_P54819

Antibodypedia

AK2 antibodies


PROTEIN BROWSER

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ENST00000354858
 
ENST00000373449
 
ENST00000467905
 
ENST00000480134
 
ENST00000487289
 
ENST00000548033
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AK2-001 ENSP00000346921
ENST00000354858
P54819
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Show » Show » 239 26.5 No 0
AK2-002 ENSP00000362548
ENST00000373449
P54819
Show all »
Show » Show » 232 25.6 No 0
AK2-003 ENSP00000447082
ENST00000467905
F8W1A4
Show all »
Show » Show » 232 25.6 No 0
AK2-007 ENSP00000446849
ENST00000487289
F8VZG5
Show all »
Show » Show » 162 17.5 No 0
AK2-009 ENSP00000450109
ENST00000480134
G3V213
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Show » Show » 133 14.3 No 0
AK2-010 ENSP00000449003
ENST00000548033
F8VY04
Show all »
Show » Show » 190 21.2 No 0