News Articles


Validation of antibodies for bioimaging

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In a recent publication in Journal of Proteome Research, researchers from the Cell Profiling group of the Human Protein Atlas team present a new approach for validation of antibodies for bioimaging applications.

Antibodies are indispensible research tools, yet the scientific community has not adopted standardized procedures to validate their specificity. Here the researchers present a strategy to systematically validate antibodies for immunofluorescence applications using gene tagging.

Marie Skogs is the first author of the study.

– After a M. Sc...Read more


Milestone reached – 50 000 antibodies passed

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The Human Protein Atlas has since the first array validated antibody in November 2004 now passed 50 000 protein microarray validated antibodies.

The Human Protein Atlas contains information for a large majority of all human protein-coding genes regarding the expression and localization of the corresponding proteins based on both RNA and protein data. For the protein data, antibodies are used to show localization, and now 50 000 antibodies have been produced and verified within the project.

– This is a true heroic effort, says professor Peter Nilsson, site director at the SciLifeLab-site in Stockholm...Read more


Proposed guidelines for antibody validation

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An international working group has formulated directives to evaluate antibodies used in biomedical research. A paper in Nature Methods suggests five conceptual pillars for antibody validation.

Antibodies are used frequently both in research and in the clinic, and today over two million commercial antibodies are available for the analysis of human proteins. This has been accompanied with a dramatic development in clinical treatment of diseases, like cancer and autoimmune diseases, where biological drugs in the form of antibodies have changed the treatment of many patient categories...Read more


Upcoming Events


Proteomics in Cell Biology and Disease Mechanisms

February 28, 2018 - March 2, 2018

The Wellcome Genome Campus organizes the conference Proteomics in Cell Biology and Disease Mechanisms where Dr. Emma Lundberg will present "Dissecting the spatiotemporal subcellular distribution of the human proteome". Her talk is scheduled on March 2. Draft programme

US HUPO

March 11, 2018 - March 14, 2018

The title of 2018 year's US HUPO conference is "Technology accelerating discovery". Dr. Emma Lundberg will hold the closing plenary session on March 14. Programme