Some proteins are expressed periodically during a specific stage of the cell cycle or as a response to various stimuli. As a result, at any given time some cells express the protein of interest and some do not. In the Cell Atlas we denote these images as single-cell variation (SCV). An example of a protein with such variations is CCNB1.
CCNB1, shown here in U-251 MG cells, is essential for cellular proliferation. The abundance of CCNB1 oscillates across the cell cycle, and peaks during G2/M phase. CCNB1 is expressed in the cytoplasm during interphase and translocate to the nucleus during G2/M transition...Read more
September 22, 2019 - September 26, 2019
Mathias Uhlen holds the PEACe keynote lecture, titled "The Human Secretome Project - generation of all human secreted proteins in mammalian cell cultures".
September 5, 2019