In an article in "Onkologi i Sverige" (Swedish) Prof. Fredrik Pontén has written an article on the history, background and development of the Human Protein Atlas project. General strategies and historic milestones are described as well as an update of the current status of the three main parts of the current version of the Human Protein Atlas; the Normal Tissue Atlas, the Cell Atlas and the recent Pathology Atlas.
Read the full article (in Swedish)...Read more
Some proteins are expressed periodically during a specific stage of the cell cycle or as a response to various stimuli. As a result, at any given time some cells express the protein of interest and some do not. In the Cell Atlas we denote these images as single-cell variation (SCV). An example of a protein with such variations is CCNB1.
CCNB1, shown here in U-251 MG cells, is essential for cellular proliferation. The abundance of CCNB1 oscillates across the cell cycle, and peaks during G2/M phase. CCNB1 is expressed in the cytoplasm during interphase and translocate to the nucleus during G2/M transition...Read more
SUN2 (Sad1 and UNC84 domain containing 2), found in the nuclear membrane of cells, is an essential protein for many cellular processes. SUN plays a large role in the organization of multi-nucleated muscle cells, and dysregulation of SUN can cause muscular dystrophy among other diseases...Read more
Autophagosomes play a crucial role in recycling, by degrading cellular components and providing building blocks for renewal och cell components. Last year, we published a post about autophagy, which was the subject of the 2016 Nobel Prize in Physiology and Medicine.
We show, for the first time, images of HPA antibodies that co-localize with the autophagosomes. These membrane bound vesicles are involved in degradation of cellular constituents through a process called autophagy. The protein detected is localized to the autophagosomes (green) in SH-SY5Y cells, a human neuroblastoma cell line from neural tissue...Read more
The American Society for Cell Biology (ASCB) and the European Molecular Biology Organization (EMBO) jointly organize the first international conference on cell biology of brain. The ASCB/EMBO meeting takes place in Philadelphia on the 2-4 of December 2017. The conference brings together a program covering presentations from molecular structure and function analysis to signalling pathways, immunity and cellular interplay in organoids...Read more
June 16, 2018 - June 20, 2018
On Tuesday June 19, Jochen Schwenk will present "An update on the Human Plasma Proteome" at the XII EuPA Congress - Translating genomes into biological functions.