The advances in histology and cytology, and biology as a whole, wouldn't have been possible without the invention of the microscope. To enlarge objects multiple times, and to be able to study these objects much more closely has contributed a great deal to science, if not the most...Read more
A bit more than two decades ago, the first Diablo game was released to the world. A game about a lone hero tasked with bringing down Diablo, one of the lords of Hell. This month we highlight a namesake to this hellish lord of terror, the protein DIABLO...Read more
In an article in "Onkologi i Sverige" (Swedish) Prof. Fredrik Pontén has written an article on the history, background and development of the Human Protein Atlas project. General strategies and historic milestones are described as well as an update of the current status of the three main parts of the current version of the Human Protein Atlas; the Normal Tissue Atlas, the Cell Atlas and the recent Pathology Atlas.
Read the full article (in Swedish)...Read more
Some proteins are expressed periodically during a specific stage of the cell cycle or as a response to various stimuli. As a result, at any given time some cells express the protein of interest and some do not. In the Cell Atlas we denote these images as single-cell variation (SCV). An example of a protein with such variations is CCNB1.
CCNB1, shown here in U-251 MG cells, is essential for cellular proliferation. The abundance of CCNB1 oscillates across the cell cycle, and peaks during G2/M phase. CCNB1 is expressed in the cytoplasm during interphase and translocate to the nucleus during G2/M transition...Read more
SUN2 (Sad1 and UNC84 domain containing 2), found in the nuclear membrane of cells, is an essential protein for many cellular processes. SUN plays a large role in the organization of multi-nucleated muscle cells, and dysregulation of SUN can cause muscular dystrophy among other diseases...Read more