THE HUMAN PROTEIN ATLAS BLOG

The face of Image of the Week

2016-12-13
Cell Atlas Cell cycle Imaging Proteomics

Devin Sullivan

Over the last couple of months, you have hade the pleasure to see Image of the week here on the blog, where an image we find particularly interesting has been shown and discussed. Now that our Cell Atlas is out, you can browse images of your favorite protein directly in our database! In addition to all the images we have added, there are also new "Human Cell" chapters, which provide a knowledge-based analysis of the human cellular proteomes and an entry into the Human Protein Atlas from different perspectives...Read more


Image of the week - the cell cycle and mitosis

2016-07-01
Cell cycle Image of the week Mitosis Subcell Atlas

Figure 1. Selected cells from the Subcellular HPA showing the progression of the stages of mitosis (clockwise), with DNA (blue) and microtubules (red) in U-2 OS cells.

It's time for another Image of the week! This week's image is brought to us by Diana Mahdessian, who works on the Subcellular protein atlas, and highlights cell division and various stages of mitosis. In previous blogs we have discussed the importance of certain proteins in the cell cycle including dividing centrosomes and FDXR in mitochondria.

The cell cycle is an ordered series of events that ultimately leads to the division of the "mother" cell into two "daughter" cells (cells are given feminine names because they are capable of reproducing).

The cell cycle consists of three distinct phases; interphase, mitosis and cytokinesis...Read more


Image of the week - CDC42 and actin filaments

2016-05-06
Actin Cell cycle Image of the week Immunofluorescence Subcell Atlas

Fig 1. Staining of CDC42EP4 (green) with DAPI (blue) and microtubules (red) in U2 OS cells.

This week HPA image of the week, I've decided to highlight two of my favorite things, the cell cycle and actin filaments!

The protein labeled in Fig 1. is an image of Cell division cycle 42 effector protein (Rho GTPase binding) 4 (CDC42EP4). In addition to being quite a mouthful, this protein resides in the cytoplasm and is associated with the actin filaments. In this image, CDC42EP4 is seen in U-2 OS human osteosarcoma cells.

As the name suggests, the CDC42EP4 is a protein associated with CDC42, which helps regulate the transition from G1 to S (in which DNA is replicated), and is essential for proper cell cycle progression (Yasuda S et al. 2006)...Read more