News Articles


CD44 as a marker of renal cancer

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Renal cell cancer is a relatively common form of human cancer. Tumors develop in the kidney and have a tendency to grow into renal veins and metastasize to distant organs without the spread to regional lymph nodes as is common for many other tumor types.

This particular case shows a papillary form of renal cell cancer that grows with papillary excrescences into cyst formations and with areas of necrosis. The tumor has been stained with an antibody (HPA005785) that recognizes the CD44 protein.

CD44 is a cell-surface glycoprotein and a receptor for hyaluronic acid that is involved in cell-cell interactions, cell adhesion and migration...Read more


Tissue Atlas: microscopy and annotation

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Today, we are back in the Tissue Atlas facilities at the Rudbeck lab in Uppsala. Borbala Katona and Maria Aronsson are research engineers in the group working with microscopy and annotation of stained tissues, which we described last week.

Borbala Katona has a bachelors degree in biomedicine and a masters degree in infectious medicine and has been working within the Human Protein Atlas since 2014.

Maria Aronsson has a masters degree in medical biology from Linköping University and joined the Human Protein Atlas in 2012...Read more


The Retina and the proteins expressed within

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More than a century ago, Piccolino M. Cajal published his groundbreaking work on the retina. At that time, Cajal was eager to confirm previous observations he had made in other neural tissues, and he considered the retina very suitable to study due to its simple organization and structure.

The human retina is a multilayered neural tissue that originates from the developing brain, and populates the innermost layer of the eye, called the inner photosensitive layer. The retina is composed of polarized photosensitive neurons called rods and cones...Read more


Tissue Atlas: production and staining

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Today, we start a "mini-series" about our Tissue Atlas here at the blog. Join us on a tour through the lab, meet some of the people working there, and see some really nice images produced by the scientists.

All the work on our Tissue Atlas is done at our Uppsala site, with Cecilia Lindskog as site director. You can learn all about her in one of our previous blog posts.

First we meet research engineer IngMarie Olsson who is group leader for the Tissue Microarray Production, Immunohistochemistry, and Scanning-group...Read more


New treatment attacking liver disease and diabetes

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Researchers from the Human Protein Atlas are planning a clinical trial of a new treatment for nonalcoholic fatty liver disease and type 2 diabetes which harnesses liver cells own ability to burn accumulated fats...Read more


Upcoming Events


The 13th International Conference on Genomics

October 24, 2018 - October 28, 2018

Mathias Uhlen will present "The creation of a mammalian protein brain atlas" at the 13th International Conference on Genomics taking place in Shenzhen, China. His talk is scheduled at 15.20 on October 26.
Programme

Biomarkers – methods and technologies

October 25, 2018 - October 26, 2018

Dr. Jochen Schwenk will give a talk on "Affinity-based assays for biomarkers of the plasma proteome", at the 14th Annual Workshop of Biofilms - Research Center for Biointerfaces, which focuses on Biomarkers - methods and technology.
Programme